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LOX | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa) | ||||
CALML5 | Calmodulin like 5. (149 aa) | ||||
TRPC3 | Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa) | ||||
LRRC38 | Leucine rich repeat containing 38. (294 aa) | ||||
TXNRD1 | Thioredoxin reductase 1, cytoplasmic. (651 aa) | ||||
HMOX1 | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. (287 aa) | ||||
CALM3 | Uncharacterized protein; Belongs to the calmodulin family. (214 aa) | ||||
FBXO9 | F-box domain-containing protein. (448 aa) | ||||
CALML4 | Uncharacterized protein. (154 aa) | ||||
TRPC6 | Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (939 aa) | ||||
TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (924 aa) | ||||
ARRB2 | Arrestin beta 2. (493 aa) | ||||
TXN | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (169 aa) | ||||
PRKACB | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa) | ||||
TRPC1 | Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa) | ||||
LRRC26 | Leucine rich repeat containing 26. (331 aa) | ||||
FBXO32 | F-box only protein 32; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity). (425 aa) | ||||
KEAP1 | Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...] (624 aa) | ||||
CRBN | Cereblon. (444 aa) | ||||
SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa) | ||||
INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) | ||||
GSR | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (519 aa) | ||||
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa) | ||||
ARRB1 | Arrestin beta 1. (607 aa) | ||||
KCNMA1 | Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] (1288 aa) | ||||
CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) | ||||
LRRC55 | Leucine rich repeat containing 55. (297 aa) | ||||
NOX4 | NADPH oxidase 4. (578 aa) | ||||
NOX1 | NADPH oxidase 1 isoform 1. (564 aa) | ||||
NFATC3 | Nuclear factor of activated T cells 3. (1149 aa) | ||||
LRRC52 | Leucine rich repeat containing 52. (315 aa) | ||||
ACE | Angiotensin-converting enzyme. (1309 aa) | ||||
NFE2L2 | Nuclear factor, erythroid 2 like 2. (656 aa) |