STRINGSTRING
ACAA2 ACAA2 RDH5 RDH5 LOC106504545 LOC106504545 RETSAT RETSAT HADHA HADHA ACAA1 ACAA1 SLC25A20 SLC25A20 RETNLB RETNLB CPT1A CPT1A PC PC SERPING1 SERPING1 FMOD FMOD ACLY ACLY SLC2A4 SLC2A4 FASN FASN PDHA1 PDHA1 RETN RETN BGN BGN SLC4A1 SLC4A1 MGLL MGLL TXNIP TXNIP LDHA LDHA LOC106504547 LOC106504547 RDH16 RDH16 INS INS PYGL PYGL ADIPOQ ADIPOQ ACACA ACACA PYGM PYGM LIPE LIPE ACSS2 ACSS2 SERPINA3-2 SERPINA3-2 CS CS LEP LEP AK2 AK2 DLD DLD PDHB PDHB ACADVL ACADVL PYGB PYGB CPT2 CPT2 HK1 HK1 DLAT DLAT CKB CKB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
RDH5Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (429 aa)
LOC106504545SERPIN domain-containing protein; Belongs to the serpin family. (417 aa)
RETSATAll-trans-retinol 13,14-reductase. (611 aa)
HADHATrifunctional enzyme subunit alpha, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional en [...] (763 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa)
SLC25A20Mitochondrial carnitine/acylcarnitine carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa)
RETNLBResistin-like beta protein. (111 aa)
CPT1AUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (771 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1110 aa)
SERPING1Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. (491 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). (376 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1130 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. (509 aa)
FASNUncharacterized protein. (1430 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. (396 aa)
RETNResistin. (109 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (338 aa)
SLC4A1Anion exchange protein. (924 aa)
MGLLMonoglyceride lipase. (456 aa)
TXNIPThioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and co [...] (391 aa)
LDHAL-lactate dehydrogenase A chain. (443 aa)
LOC106504547SERPIN domain-containing protein; Belongs to the serpin family. (445 aa)
RDH16Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (854 aa)
ADIPOQC1q domain-containing protein. (332 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (1369 aa)
LIPEHormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (1057 aa)
ACSS2Acetyl-coenzyme A synthetase, cytoplasmic isoform X1. (714 aa)
SERPINA3-2SERPIN domain-containing protein; Belongs to the serpin family. (473 aa)
CSCitrate synthase, mitochondrial; Belongs to the citrate synthase family. (464 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
AK2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (267 aa)
DLDDihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex) (By similarity). The 2- oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA t [...] (511 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (361 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (681 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
CPT2Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (658 aa)
HK1Uncharacterized protein. (919 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (667 aa)
CKBCreatine kinase B-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. (403 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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