STRINGSTRING
SERPINB8 SERPINB8 MMP2 MMP2 COL21A1 COL21A1 COL11A1 COL11A1 MATN4 MATN4 COL8A1 COL8A1 LTBP4 LTBP4 KNG1 KNG1 C1QTNF7 C1QTNF7 SERPINC1 SERPINC1 FRAS1 FRAS1 DEPTOR DEPTOR CXCL12 CXCL12 COL1A1 COL1A1 COL6A1 COL6A1 COL14A1 COL14A1 MGP MGP HAPLN3 HAPLN3 LGALS3 LGALS3 PLOD3 PLOD3 COL4A1 COL4A1 CILP CILP FREM1 FREM1 COL28A1 COL28A1 MMRN2 MMRN2 SERPINF2 SERPINF2 ACAN ACAN MFAP4 MFAP4 SERPINF1 SERPINF1 SERPINE2 SERPINE2 MATN2 MATN2 ELN ELN COL4A5 COL4A5 ADIPOQ ADIPOQ NID2 NID2 THBS3 THBS3 ADAMTSL1 ADAMTSL1 TIMP3 TIMP3 C1QTNF2 C1QTNF2 COL2A1 COL2A1 SERPINB12 SERPINB12 P4HA1 P4HA1 COL16A1 COL16A1 COL3A1 COL3A1 TNFSF13 TNFSF13 COL18A1 COL18A1 TNXB TNXB S100A10 S100A10 TGFB1 TGFB1 S100A2 S100A2 S100A1 S100A1 BGN BGN LOC110260465 LOC110260465 SDC1 SDC1 AMBP AMBP TGM1 TGM1 CD109 CD109 COL17A1 COL17A1 COL6A2 COL6A2 VTN VTN THBS4 THBS4 LAMB3 LAMB3 LAMC2 LAMC2 HAPLN1 HAPLN1 COL5A3 COL5A3 VEGFB VEGFB COL7A1 COL7A1 NGLY1 NGLY1 CTSV CTSV VWA2 VWA2 COL4A2 COL4A2 FREM2 FREM2 MMRN1 MMRN1 ANXA5 ANXA5 ANXA4 ANXA4 FBLN7 FBLN7 ASPN ASPN S100A7 S100A7 COL5A1 COL5A1 LAMC3 LAMC3 COL15A1 COL15A1 THSD4 THSD4 LUM LUM LOXL1 LOXL1 SERPINA12 SERPINA12 LAMA3 LAMA3 COL10A1 COL10A1 COL12A1 COL12A1 FBN1 FBN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SERPINB8Serpin family B member 8; Belongs to the serpin family. (374 aa)
MMP2Uncharacterized protein. (610 aa)
COL21A1Collagen type XXI alpha 1 chain. (957 aa)
COL11A1Collagen type XI alpha 1 chain. (1816 aa)
MATN4Matrilin 4. (774 aa)
COL8A1Collagen type VIII alpha 1 chain. (759 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1622 aa)
KNG1Kininogen 1. (630 aa)
C1QTNF7C1q and TNF related 7. (311 aa)
SERPINC1SERPIN domain-containing protein; Belongs to the serpin family. (431 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4013 aa)
DEPTORDEP domain-containing mTOR-interacting protein isoform 1. (409 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
COL6A1Collagen type VI alpha 1 chain. (1028 aa)
COL14A1Collagen alpha-1(XIV) chain isoform X1. (1796 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. (127 aa)
HAPLN3Hyaluronan and proteoglycan link protein 3. (470 aa)
LGALS3Galectin. (271 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (744 aa)
COL4A1Collagen IV NC1 domain-containing protein. (461 aa)
CILPCartilage intermediate layer protein 1 C2; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity). (1193 aa)
FREM1FRAS1 related extracellular matrix 1. (2182 aa)
COL28A1Collagen type XXVIII alpha 1 chain. (1236 aa)
MMRN2Multimerin 2. (931 aa)
SERPINF2Alpha-2-antiplasmin isoform X2; Belongs to the serpin family. (563 aa)
ACANAggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2434 aa)
MFAP4Microfibril associated protein 4. (304 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (433 aa)
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (378 aa)
MATN2Matrilin 2. (956 aa)
ELNElastin. (674 aa)
COL4A5Collagen type IV alpha 5 chain. (1689 aa)
ADIPOQC1q domain-containing protein. (332 aa)
NID2Nidogen 2. (1348 aa)
THBS3Thrombospondin-3 isoform 1. (973 aa)
ADAMTSL1ADAMTS like 1. (1763 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
C1QTNF2C1q and TNF related 2. (396 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
SERPINB12Serpin family B member 12; Belongs to the serpin family. (425 aa)
P4HA1Prolyl 4-hydroxylase subunit alpha-1 isoform 1. (534 aa)
COL16A1Collagen alpha-1(XVI) chain isoform X2. (1624 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
TNFSF13TNF superfamily member 13; Belongs to the tumor necrosis factor family. (251 aa)
COL18A1Collagen type XVIII alpha 1 chain. (1755 aa)
TNXBUncharacterized protein. (4137 aa)
S100A10Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (97 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
S100A2S100 calcium binding protein A2. (170 aa)
S100A1S100 calcium binding protein A1; Belongs to the S-100 family. (181 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (338 aa)
LOC110260465EF-hand domain-containing protein. (100 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (309 aa)
AMBPInter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. (364 aa)
TGM1Protein-glutamine gamma-glutamyltransferase K. (826 aa)
CD109CD109 antigen isoform 1 preproprotein. (1449 aa)
COL17A1Collagen type XVII alpha 1 chain. (1506 aa)
COL6A2Collagen type VI alpha 2 chain. (943 aa)
VTNVitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). (523 aa)
THBS4Thrombospondin 4. (976 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
LAMC2Laminin subunit gamma-2 isoform a. (1191 aa)
HAPLN1Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; Belongs to the HAPLN family. (354 aa)
COL5A3Collagen type V alpha 3 chain. (1747 aa)
VEGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (465 aa)
COL7A1Uncharacterized protein. (2938 aa)
NGLY1N-glycanase 1. (688 aa)
CTSVCathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (334 aa)
VWA2Von Willebrand factor A domain containing 2. (735 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
FREM2FRAS1 related extracellular matrix 2. (3174 aa)
MMRN1Multimerin 1. (1220 aa)
ANXA5Annexin. (321 aa)
ANXA4Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Belongs to the annexin family. (337 aa)
FBLN7Fibulin 7. (569 aa)
ASPNAsporin. (370 aa)
S100A7EF-hand domain-containing protein. (101 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
COL15A1Collagen type XV alpha 1 chain. (1359 aa)
THSD4Thrombospondin type-1 domain-containing protein 4 isoform X1. (1014 aa)
LUMLumican. (341 aa)
LOXL1Lysyl oxidase like 1. (591 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (414 aa)
LAMA3Laminin subunit alpha 3. (3345 aa)
COL10A1Type X collagen. (675 aa)
COL12A1Collagen type XII alpha 1 chain. (3065 aa)
FBN1Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2871 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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