node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | BGN | ENSSSCP00000052661 | ENSSSCP00000029666 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Biglycan; May be involved in collagen fiber assembly. | 0.899 |
ACAN | CD34 | ENSSSCP00000052661 | ENSSSCP00000038479 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | CD34 molecule. | 0.621 |
ACAN | CD44 | ENSSSCP00000052661 | ENSSSCP00000014130 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | CD44 molecule (Indian blood group). | 0.682 |
ACAN | COL1A1 | ENSSSCP00000052661 | ENSSSCP00000066291 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen type I alpha 1 chain. | 0.813 |
ACAN | COL2A1 | ENSSSCP00000052661 | ENSSSCP00000036099 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen type II alpha 1 chain. | 0.950 |
ACAN | ENG | ENSSSCP00000052661 | ENSSSCP00000030121 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] | 0.477 |
ACAN | FOXF1 | ENSSSCP00000052661 | ENSSSCP00000042203 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Forkhead box protein F1. | 0.447 |
ACAN | GDF5 | ENSSSCP00000052661 | ENSSSCP00000023243 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Growth differentiation factor 5. | 0.663 |
ACAN | ITGB1 | ENSSSCP00000052661 | ENSSSCP00000030775 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.572 |
ACAN | NANOG | ENSSSCP00000052661 | ENSSSCP00000056364 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Homeobox domain-containing protein. | 0.445 |
ACAN | PAX1 | ENSSSCP00000052661 | ENSSSCP00000007575 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Paired box 1. | 0.460 |
ACAN | SOX9 | ENSSSCP00000052661 | ENSSSCP00000018278 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | 0.945 |
ACAN | THY1 | ENSSSCP00000052661 | ENSSSCP00000050686 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Thy-1 cell surface antigen. | 0.498 |
BGN | ACAN | ENSSSCP00000029666 | ENSSSCP00000052661 | Biglycan; May be involved in collagen fiber assembly. | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.899 |
BGN | CD44 | ENSSSCP00000029666 | ENSSSCP00000014130 | Biglycan; May be involved in collagen fiber assembly. | CD44 molecule (Indian blood group). | 0.543 |
BGN | COL1A1 | ENSSSCP00000029666 | ENSSSCP00000066291 | Biglycan; May be involved in collagen fiber assembly. | Collagen type I alpha 1 chain. | 0.881 |
BGN | COL2A1 | ENSSSCP00000029666 | ENSSSCP00000036099 | Biglycan; May be involved in collagen fiber assembly. | Collagen type II alpha 1 chain. | 0.715 |
BGN | COL5A1 | ENSSSCP00000029666 | ENSSSCP00000006161 | Biglycan; May be involved in collagen fiber assembly. | Fibrillar collagen NC1 domain-containing protein. | 0.672 |
BGN | SOX9 | ENSSSCP00000029666 | ENSSSCP00000018278 | Biglycan; May be involved in collagen fiber assembly. | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | 0.445 |
CD151 | CD44 | ENSSSCP00000013650 | ENSSSCP00000014130 | Tetraspanin. | CD44 molecule (Indian blood group). | 0.502 |