STRINGSTRING
ITGB1 ITGB1 MYC MYC KLF4 KLF4 KRT18 KRT18 COL1A1 COL1A1 NANOG NANOG ACAN ACAN THY1 THY1 KRT8 KRT8 FOXF1 FOXF1 CD19 CD19 CD34 CD34 COL2A1 COL2A1 FOXA2 FOXA2 ENG ENG BGN BGN NES NES GDF5 GDF5 SOX9 SOX9 CD44 CD44 CD151 CD151 SFRP2 SFRP2 PAX1 PAX1 COL5A1 COL5A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
KLF4Kruppel-like factor 4 isoform b. (510 aa)
KRT18Keratin 18; Belongs to the intermediate filament family. (423 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
NANOGHomeobox domain-containing protein. (304 aa)
ACANAggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2434 aa)
THY1Thy-1 cell surface antigen. (165 aa)
KRT8Keratin, type II cytoskeletal 8 isoform 2; Belongs to the intermediate filament family. (461 aa)
FOXF1Forkhead box protein F1. (423 aa)
CD19CD19 molecule. (645 aa)
CD34CD34 molecule. (393 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
FOXA2Hepatocyte nuclear factor 3-beta isoform 1. (463 aa)
ENGEndoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (338 aa)
NESNestin; Belongs to the intermediate filament family. (1699 aa)
GDF5Growth differentiation factor 5. (499 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
CD44CD44 molecule (Indian blood group). (767 aa)
CD151Tetraspanin. (264 aa)
SFRP2Uncharacterized protein. (294 aa)
PAX1Paired box 1. (454 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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