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TP53 TP53 MITF MITF RASGRP3 RASGRP3 TFAP2A TFAP2A TEAD1 TEAD1 CXCR4 CXCR4 PRKACB PRKACB CCND1 CCND1 PLCB2 PLCB2 CCR10 CCR10 FZD4 FZD4 ARRB2 ARRB2 PLCB1 PLCB1 CXCL12 CXCL12 CCN1 CCN1 EDN3 EDN3 ADA ADA LDLR LDLR GNB1 GNB1 WNT1 WNT1 GRM4 GRM4 THBS1 THBS1 ESR2 ESR2 TYRP1 TYRP1 XPA XPA GPR161 GPR161 ADCY10 ADCY10 CREBBP CREBBP EDNRA EDNRA CYSLTR2 CYSLTR2 EDNRB EDNRB DCT DCT FZD10 FZD10 PTEN PTEN GRM2 GRM2 RHO RHO GPR143 GPR143 LRP5 LRP5 GRM6 GRM6 GRM3 GRM3 GNAI1 GNAI1 GLI2 GLI2 FZD7 FZD7 ADCY1 ADCY1 AEBP1 AEBP1 CCR7 CCR7 NF1 NF1 GNA11 GNA11 ADCY5 ADCY5 PAX3 PAX3 WNT3A WNT3A POMC POMC GRM8 GRM8 RABIF RABIF GPER1 GPER1 GRM5 GRM5 TYR TYR SRC SRC AMOT AMOT ESR1 ESR1 GNB5 GNB5 ARRB1 ARRB1 YAP1 YAP1 LEF1 LEF1 CRTC3 CRTC3 PRKACA PRKACA F2R F2R PRKX PRKX BRAF BRAF SOX10 SOX10 PRKCB PRKCB GPR143-2 GPR143-2 WNT5A WNT5A FZD1 FZD1 EDN1 EDN1 LATS1 LATS1 TLE1 TLE1 GRM7 GRM7 RHOA RHOA NRAS NRAS ADGRV1 ADGRV1 PDE4D PDE4D GRM1 GRM1 ADCY8 ADCY8 DRD2 DRD2 ADCY9 ADCY9
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
MITFMicrophthalmia-associated transcription factor isoform 1. (520 aa)
RASGRP3RAS guanyl releasing protein 3. (692 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
TEAD1TEA domain transcription factor 1. (630 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
CCR10G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (375 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)
ARRB2Arrestin beta 2. (493 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
CCN1Cellular communication network factor 1. (382 aa)
EDN3Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. (231 aa)
ADAAdenosine deaminase. (409 aa)
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa)
GNB1G protein subunit beta 1. (395 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GRM4Glutamate metabotropic receptor 4. (966 aa)
THBS1Uncharacterized protein. (1170 aa)
ESR2Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. (526 aa)
TYRP15,6-dihydroxyindole-2-carboxylic acid oxidase. (562 aa)
XPAXPA, DNA damage recognition and repair factor. (310 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (549 aa)
ADCY10Adenylate cyclase 10. (1610 aa)
CREBBPCREB-binding protein isoform a. (2440 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
CYSLTR2Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). (361 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (443 aa)
DCTL-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. (519 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
PTENUncharacterized protein. (576 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
RHORhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa)
GPR143Uncharacterized protein. (405 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
GRM6Glutamate metabotropic receptor 6. (872 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1. (354 aa)
GLI2GLI family zinc finger 2. (1551 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1136 aa)
AEBP1Adipocyte enhancer-binding protein 1. (1140 aa)
CCR7G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (477 aa)
NF1Neurofibromin 1. (2847 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C (By similarity). (359 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
PAX3Paired box protein Pax-3 isoform PAX3e. (484 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
POMCCorticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. (381 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
RABIFRAB interacting factor. (123 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
GRM5Glutamate metabotropic receptor 5. (1212 aa)
TYRTyrosinase. (531 aa)
SRCTyrosine-protein kinase. (559 aa)
AMOTAngiomotin isoform X1. (1088 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
GNB5G protein subunit beta 5. (420 aa)
ARRB1Arrestin beta 1. (607 aa)
YAP1Yes associated protein 1. (432 aa)
LEF1Lymphoid enhancer binding factor 1. (429 aa)
CRTC3CREB-regulated transcription coactivator 3 isoform a. (619 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
F2RG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PRKXUncharacterized protein; Belongs to the protein kinase superfamily. (358 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
GPR143-2Uncharacterized protein. (412 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
LATS1Large tumor suppressor kinase 1. (1146 aa)
TLE1TLE family member 1, transcriptional corepressor. (770 aa)
GRM7Metabotropic glutamate receptor 7 isoform X1. (921 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
ADGRV1Adhesion G protein-coupled receptor V1. (6313 aa)
PDE4DPhosphodiesterase. (809 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1379 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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