64 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANXA5	Annexin. (321 aa)
	KIF11	Kinesin-like protein KIF11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1059 aa)
	HELLS	Lymphoid-specific helicase isoform 1. (837 aa)
	SMC3	Structural maintenance of chromosomes protein. (1217 aa)
	TADA3	Transcriptional adapter 3 isoform a. (432 aa)
	SMC1A	Structural maintenance of chromosomes protein. (1298 aa)
	PLK5	Serine/threonine-protein kinase PLK. (611 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1706 aa)
	GDF9	Growth differentiation factor 9. (444 aa)
	RBBP5	RB binding protein 5, histone lysine methyltransferase complex subunit. (517 aa)
	CHEK1	Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. (476 aa)
	RBBP7	RB binding protein 7, chromatin remodeling factor. (469 aa)
	TDRKH	Tudor and KH domain containing. (611 aa)
	MYO1E	Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1116 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (835 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (1085 aa)
	MYO5B	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1845 aa)
	PLAA	Phospholipase A2 activating protein. (1044 aa)
	DR1	Down-regulator of transcription 1. (176 aa)
	PLPP3	acidPPc domain-containing protein. (369 aa)
	NDC80	NDC80 kinetochore complex component. (677 aa)
	PLPP2	Phospholipid phosphatase 2. (368 aa)
	PPP3R1	Uncharacterized protein. (188 aa)
	ANXA8	Annexin. (354 aa)
	SMC1B	Structural maintenance of chromosomes protein. (1235 aa)
	SLC16A1	Solute carrier family 16, member 1 (Monocarboxylic acid transporter 1) tv1. (501 aa)
	KIF15	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1395 aa)
	MYO1B	Myosin IB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1136 aa)
	KIF20A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (890 aa)
	KIF14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1532 aa)
	CD276	CD276 molecule. (537 aa)
	KIF20B	Kinesin-like protein KIF20B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1787 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2383 aa)
	KIF4A	Kinesin family member 4A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1195 aa)
	RBBP4	WD_REPEATS_REGION domain-containing protein. (427 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa)
	TPM4	Tropomyosin alpha-4 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. (284 aa)
	ANXA13	Annexin. (357 aa)
	MSMO1	Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family. (293 aa)
	SMC4	Structural maintenance of chromosomes protein. (1250 aa)
	LPIN2	Lipin 2. (937 aa)
	ANXA11	Annexin. (516 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa)
	SLC16A3	Solute carrier family 16 member 3. (458 aa)
	CD59	CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. (123 aa)
	TDRD1	Tudor domain containing 1. (1177 aa)
	PLK1	Serine/threonine-protein kinase PLK. (601 aa)
	CCNB1	Cyclin B1 transcript variant 1; Belongs to the cyclin family. (435 aa)
	ANXA7	Annexin. (485 aa)
	CORO1C	Coronin; Belongs to the WD repeat coronin family. (511 aa)
	ANXA6	Annexin. (672 aa)
	PTTG1	Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...] (202 aa)
	PLK2	Serine/threonine-protein kinase PLK. (685 aa)
	PLPP1	Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these [...] (290 aa)
	WEE2	Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. (565 aa)
	CPEB1	Uncharacterized protein. (602 aa)
	PLK3	Serine/threonine-protein kinase PLK. (647 aa)
	KIF23	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (967 aa)
	ANXA1	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
	SMC2	Structural maintenance of chromosomes protein. (1191 aa)
	MOS	Proto-oncogene serine/threonine-protein kinase mos. (345 aa)
	ANXA9	Annexin. (360 aa)
	UBE2C	Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
	TXNDC9	Thioredoxin domain-containing protein 9. (226 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	LPIN2	ENSSSCP00000047454	ENSSSCP00000033369	Acetyl-CoA carboxylase alpha.	Lipin 2.	0.429
ANXA1	ANXA13	ENSSSCP00000005658	ENSSSCP00000037349	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	Annexin.	0.470
ANXA1	ANXA5	ENSSSCP00000005658	ENSSSCP00000009706	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	Annexin.	0.452
ANXA13	ANXA1	ENSSSCP00000037349	ENSSSCP00000005658	Annexin.	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	0.470
ANXA5	ANXA1	ENSSSCP00000009706	ENSSSCP00000005658	Annexin.	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	0.452
ANXA5	CCNB1	ENSSSCP00000009706	ENSSSCP00000023163	Annexin.	Cyclin B1 transcript variant 1; Belongs to the cyclin family.	0.572
ANXA5	DNMT1	ENSSSCP00000009706	ENSSSCP00000014522	Annexin.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.419
ANXA5	PLK1	ENSSSCP00000009706	ENSSSCP00000023889	Annexin.	Serine/threonine-protein kinase PLK.	0.468
BUB1	CCNB1	ENSSSCP00000072094	ENSSSCP00000023163	BUB1 mitotic checkpoint serine/threonine kinase.	Cyclin B1 transcript variant 1; Belongs to the cyclin family.	0.922
BUB1	CHEK1	ENSSSCP00000072094	ENSSSCP00000016136	BUB1 mitotic checkpoint serine/threonine kinase.	Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily.	0.804
BUB1	HELLS	ENSSSCP00000072094	ENSSSCP00000011175	BUB1 mitotic checkpoint serine/threonine kinase.	Lymphoid-specific helicase isoform 1.	0.559
BUB1	KIF11	ENSSSCP00000072094	ENSSSCP00000011160	BUB1 mitotic checkpoint serine/threonine kinase.	Kinesin-like protein KIF11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.967
BUB1	KIF14	ENSSSCP00000072094	ENSSSCP00000052264	BUB1 mitotic checkpoint serine/threonine kinase.	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.633
BUB1	KIF15	ENSSSCP00000072094	ENSSSCP00000056550	BUB1 mitotic checkpoint serine/threonine kinase.	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.936
BUB1	KIF20A	ENSSSCP00000072094	ENSSSCP00000053967	BUB1 mitotic checkpoint serine/threonine kinase.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.947
BUB1	KIF20B	ENSSSCP00000072094	ENSSSCP00000048863	BUB1 mitotic checkpoint serine/threonine kinase.	Kinesin-like protein KIF20B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.705
BUB1	KIF23	ENSSSCP00000072094	ENSSSCP00000005344	BUB1 mitotic checkpoint serine/threonine kinase.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.900
BUB1	KIF4A	ENSSSCP00000072094	ENSSSCP00000046522	BUB1 mitotic checkpoint serine/threonine kinase.	Kinesin family member 4A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.914
BUB1	MOS	ENSSSCP00000072094	ENSSSCP00000006661	BUB1 mitotic checkpoint serine/threonine kinase.	Proto-oncogene serine/threonine-protein kinase mos.	0.480
BUB1	NDC80	ENSSSCP00000072094	ENSSSCP00000067142	BUB1 mitotic checkpoint serine/threonine kinase.	NDC80 kinetochore complex component.	0.970