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TRPV1 TRPV1 LEP LEP SMAD2 SMAD2 RBM14 RBM14 NOTCH1 NOTCH1 YTHDC1 YTHDC1 YTHDF3 YTHDF3 PDE4D PDE4D FTO FTO METTL14 METTL14 REN REN PECAM1 PECAM1 HNRNPA2B1 HNRNPA2B1 WTAP WTAP ALKBH5 ALKBH5 PLSCR4 PLSCR4 YTHDF1 YTHDF1 ICAM1 ICAM1 FOXO1 FOXO1 JAK2 JAK2 HNRNPC HNRNPC CSF2 CSF2 STAT3 STAT3 HGF HGF RBM15B RBM15B ZC3H13 ZC3H13 HNRNPD HNRNPD VCAM1 VCAM1 RBM15 RBM15 VIRMA VIRMA TFEB TFEB KLF4 KLF4 RYR2 RYR2 TLR2 TLR2 MYOCD MYOCD CUX1 CUX1 YTHDF2 YTHDF2
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (832 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
SMAD2Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] (472 aa)
RBM14RNA-binding protein 14 isoform 1. (669 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
YTHDC1YTH domain containing 1. (743 aa)
YTHDF3YTH domain-containing family protein 3 isoform b. (588 aa)
PDE4DPhosphodiesterase. (809 aa)
FTOFTO_NTD domain-containing protein. (509 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
RENRenin preproprotein; Belongs to the peptidase A1 family. (407 aa)
PECAM1Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa)
HNRNPA2B1Heterogeneous nuclear ribonucleoprotein A2/B1. (369 aa)
WTAPUncharacterized protein. (649 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
PLSCR4Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (330 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (652 aa)
ICAM1Intercellular adhesion molecule 1. (537 aa)
FOXO1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (662 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
HNRNPCHeterogeneous nuclear ribonucleoproteins C1/C2 isoform X1. (307 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
RBM15BRNA binding motif protein 15B. (854 aa)
ZC3H13Zinc finger CCCH-type containing 13. (1640 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D0 isoform a. (355 aa)
VCAM1Uncharacterized protein. (537 aa)
RBM15RNA binding motif protein 15. (1006 aa)
VIRMAVir like m6A methyltransferase associated. (1812 aa)
TFEBTranscription factor EB. (451 aa)
KLF4Kruppel-like factor 4 isoform b. (510 aa)
RYR2Ryanodine receptor 2. (4966 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
MYOCDMyocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). (993 aa)
CUX1Homeobox protein cut-like. (1642 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (600 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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