STRINGSTRING
POU5F1 POU5F1 SRSF3 SRSF3 LIN28A LIN28A VIRMA VIRMA HORMAD1 HORMAD1 ZC3H13 ZC3H13 DGCR8 DGCR8 EIF4G2 EIF4G2 NCL NCL DROSHA DROSHA MEIOC MEIOC SPDL1 SPDL1 YTHDF1 YTHDF1 HNRNPU HNRNPU UPF1 UPF1 ALKBH5 ALKBH5 WTAP WTAP METTL4 METTL4 XRN1 XRN1 CCN1 CCN1 CLTC CLTC YTHDF2 YTHDF2 PCNT PCNT NANOG NANOG MOV10 MOV10 YTHDC1 YTHDC1 YTHDC2 YTHDC2 YTHDF3 YTHDF3 FTO FTO SRSF7 SRSF7 METTL14 METTL14 METTL16 METTL16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POU5F1POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Belongs to the POU transcription factor family. Class-5 subfamily. (361 aa)
SRSF3Serine and arginine rich splicing factor 3. (164 aa)
LIN28AProtein lin-28 homolog A. (205 aa)
VIRMAVir like m6A methyltransferase associated. (1812 aa)
HORMAD1HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...] (394 aa)
ZC3H13Zinc finger CCCH-type containing 13. (1640 aa)
DGCR8Microprocessor complex subunit DGCR8 isoform 1. (807 aa)
EIF4G2Eukaryotic translation initiation factor 4 gamma 2. (949 aa)
NCLZinc finger protein Pegasus. (724 aa)
DROSHADrosha ribonuclease III. (1397 aa)
MEIOCMeiosis specific with coiled-coil domain. (940 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (605 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (652 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform a. (825 aa)
UPF1UPF1 RNA helicase and ATPase. (1127 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
WTAPUncharacterized protein. (649 aa)
METTL4Methyltransferase like 4; Belongs to the MT-A70-like family. (478 aa)
XRN15'-3' exoribonuclease 1. (1703 aa)
CCN1Cellular communication network factor 1. (382 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1702 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (600 aa)
PCNTPACT_coil_coil domain-containing protein. (2015 aa)
NANOGHomeobox domain-containing protein. (304 aa)
MOV10Mov10 RISC complex RNA helicase. (1093 aa)
YTHDC1YTH domain containing 1. (743 aa)
YTHDC2YTH domain containing 2. (1430 aa)
YTHDF3YTH domain-containing family protein 3 isoform b. (588 aa)
FTOFTO_NTD domain-containing protein. (509 aa)
SRSF7Serine/arginine-rich splicing factor 7 isoform 1. (238 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
METTL16U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (561 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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