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IGDCC4 IGDCC4 CDH1 CDH1 CDHR2 CDHR2 CDH13 CDH13 LGALS3 LGALS3 IFITM1 IFITM1 COL14A1 COL14A1 DEPTOR DEPTOR IL6R IL6R CADM4 CADM4 CDHR1 CDHR1 TM4SF4 TM4SF4 COL11A1 COL11A1 PTH1R PTH1R LTBP2 LTBP2 COL13A1 COL13A1 DSP DSP PDPN PDPN EPHA2 EPHA2 WNT4 WNT4 CDH2 CDH2 LAMA4 LAMA4 COL10A1 COL10A1 COL12A1 COL12A1 CDH20 CDH20 COL15A1 COL15A1 COL5A1 COL5A1 JAG1 JAG1 BMP7 BMP7 COL26A1 COL26A1 OMD OMD SPP1 SPP1 COL4A2 COL4A2 ITGA8 ITGA8 CCR1 CCR1 COL7A1 COL7A1 LRIG1 LRIG1 PPARG PPARG GPM6B GPM6B CD44 CD44 CAPN5 CAPN5 FMOD FMOD LAMB1 LAMB1 LAMB3 LAMB3 FZD5 FZD5 EPHA4 EPHA4 ITGA2 ITGA2 WNT3A WNT3A LRRC15 LRRC15 PXDN PXDN CDHR3 CDHR3 CDH4 CDH4 SERPINE1 SERPINE1 WNT9A WNT9A COL6A3 COL6A3 WNT7B WNT7B ITGA3 ITGA3 CD109 CD109 CDH11 CDH11 GPC3 GPC3 CHRDL1 CHRDL1 ITGB1 ITGB1 GPNMB GPNMB ENPP2 ENPP2 CACNA2D2 CACNA2D2 WNT5B WNT5B COL16A1 COL16A1 GAPDH GAPDH LTBP1 LTBP1 LRRC4B LRRC4B MADCAM1 MADCAM1 LAMA2 LAMA2 LAMA2-2 LAMA2-2 CD34 CD34 ITGA10 ITGA10 ENPP1 ENPP1 ITGA4 ITGA4 CLEC3B CLEC3B FGFR3 FGFR3 ADAM12 ADAM12 COL8A2 COL8A2 LY6K LY6K ADRB2 ADRB2 MFAP4 MFAP4 ITGBL1 ITGBL1 THY1 THY1 VASN VASN LAMB4 LAMB4 WNT2 WNT2 ITGA11 ITGA11 ACAN ACAN ADAMTS8 ADAMTS8 PMEPA1 PMEPA1 COL5A2 COL5A2 LRRC17 LRRC17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IGDCC4Immunoglobulin superfamily DCC subclass member 4. (1939 aa)
CDH1Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (925 aa)
CDHR2Cadherin related family member 2. (1342 aa)
CDH13Uncharacterized protein. (771 aa)
LGALS3Galectin. (271 aa)
IFITM1Uncharacterized protein. (147 aa)
COL14A1Collagen alpha-1(XIV) chain isoform X1. (1796 aa)
DEPTORDEP domain-containing mTOR-interacting protein isoform 1. (409 aa)
IL6RInterleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis; Belongs to the type I cytokine receptor family. Type 3 subfamily. (491 aa)
CADM4Cell adhesion molecule 4. (405 aa)
CDHR1Cadherin-related family member 1 isoform 1. (856 aa)
TM4SF4Transmembrane 4 L six family member 4. (243 aa)
COL11A1Collagen type XI alpha 1 chain. (1816 aa)
PTH1RParathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. (641 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1814 aa)
COL13A1Collagen type XIII alpha 1 chain. (726 aa)
DSPDesmoplakin. (2883 aa)
PDPNUncharacterized protein. (159 aa)
EPHA2Ephrin type-A receptor 2 isoform 1. (975 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
LAMA4Laminin subunit alpha 4. (1815 aa)
COL10A1Type X collagen. (675 aa)
COL12A1Collagen type XII alpha 1 chain. (3065 aa)
CDH20Cadherin-20 preproprotein; Cadherins are calcium-dependent cell adhesion proteins. (801 aa)
COL15A1Collagen type XV alpha 1 chain. (1359 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
COL26A1Collagen type XXVI alpha 1 chain. (439 aa)
OMDOsteomodulin. (422 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (303 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
CCR1Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
COL7A1Uncharacterized protein. (2938 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1112 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa)
GPM6BGlycoprotein M6B. (305 aa)
CD44CD44 molecule (Indian blood group). (767 aa)
CAPN5Calpain 5; Belongs to the peptidase C2 family. (692 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). (376 aa)
LAMB1Laminin subunit beta 1. (1785 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
EPHA4EPH receptor A4. (986 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1178 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LRRC15Leucine rich repeat containing 15. (581 aa)
PXDNPeroxidasin. (1529 aa)
CDHR3Cadherin related family member 3. (900 aa)
CDH4Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
SERPINE1Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. I [...] (401 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
COL6A3Collagen type VI alpha 3 chain. (2911 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1085 aa)
CD109CD109 antigen isoform 1 preproprotein. (1449 aa)
CDH11Cadherin-11 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (796 aa)
GPC3Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
CHRDL1Chordin like 1. (526 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
GPNMBGlycoprotein nmb. (565 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X3. (1006 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1068 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
COL16A1Collagen alpha-1(XVI) chain isoform X2. (1624 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (398 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1708 aa)
LRRC4BLeucine rich repeat containing 4B. (714 aa)
MADCAM1Mucosal addressin cell adhesion molecule 1 isoform a. (390 aa)
LAMA2Uncharacterized protein. (2070 aa)
LAMA2-2Uncharacterized protein. (921 aa)
CD34CD34 molecule. (393 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1352 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1055 aa)
CLEC3BC-type lectin domain family 3 member B. (202 aa)
FGFR3Fibroblast growth factor receptor. (855 aa)
ADAM12ADAM metallopeptidase domain 12. (918 aa)
COL8A2Collagen type VIII alpha 2 chain. (707 aa)
LY6KUPAR/Ly6 domain-containing protein. (157 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). (418 aa)
MFAP4Microfibril associated protein 4. (304 aa)
ITGBL1Integrin subunit beta like 1. (507 aa)
THY1Thy-1 cell surface antigen. (165 aa)
VASNVasorin isoform X2. (677 aa)
LAMB4Uncharacterized protein. (719 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1282 aa)
ACANAggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2434 aa)
ADAMTS8ADAM metallopeptidase with thrombospondin type 1 motif 8. (1019 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (288 aa)
COL5A2Collagen alpha-2(V) chain preproprotein. (1499 aa)
LRRC17Leucine rich repeat containing 17. (438 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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