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AGPAT2 AGPAT2 AGPAT4 AGPAT4 MBOAT1 MBOAT1 MTOR MTOR SPTLC3 SPTLC3 PPARG PPARG PNPLA2 PNPLA2 SMPD1 SMPD1 CD36 CD36 PLPP1 PLPP1 SPHK1 SPHK1 SOAT1 SOAT1 FASN FASN LCAT LCAT AGPAT1 AGPAT1 PLB1 PLB1 MGLL MGLL FABP4 FABP4 CDS1 CDS1 PLD1 PLD1 ACER2 ACER2 SOAT2 SOAT2 DGKA DGKA INS INS ADIPOQ ADIPOQ ZNF423 ZNF423 DGKB DGKB CHPT1 CHPT1 FGF2 FGF2 PLAAT3 PLAAT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (291 aa)
AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa)
MBOAT1Membrane bound O-acyltransferase domain containing 1; Belongs to the membrane-bound acyltransferase family. (505 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (548 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa)
PNPLA2Patatin-like phospholipase domain-containing protein 2 isoform X1. (486 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (640 aa)
CD36Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)
PLPP1Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these [...] (290 aa)
SPHK1Sphingosine kinase 1 isoform 2. (481 aa)
SOAT1O-acyltransferase. (549 aa)
FASNUncharacterized protein. (1430 aa)
LCATPhosphatidylcholine-sterol acyltransferase. (471 aa)
AGPAT1PlsC domain-containing protein. (364 aa)
PLB1Phospholipase B1. (1462 aa)
MGLLMonoglyceride lipase. (456 aa)
FABP4Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). Involved in the regulation of intramuscular fat accretion ; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (472 aa)
PLD1Phospholipase. (1074 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (274 aa)
SOAT2O-acyltransferase. (566 aa)
DGKADiacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. (785 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
ADIPOQC1q domain-containing protein. (332 aa)
ZNF423Zinc finger protein 423 isoform X2. (1292 aa)
DGKBDiacylglycerol kinase. (802 aa)
CHPT1Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (406 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
PLAAT3Phospholipase A and acyltransferase 3. (162 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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