46 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IGF2BP1	Insulin-like growth factor 2 mRNA-binding protein 1 isoform X1. (577 aa)
	RBM15B	RNA binding motif protein 15B. (854 aa)
	TET1	CXXC-type domain-containing protein. (2149 aa)
	ZC3H13	Zinc finger CCCH-type containing 13. (1640 aa)
	TET2	Tet methylcytosine dioxygenase 2. (2019 aa)
	TET3	Tet methylcytosine dioxygenase 3. (1660 aa)
	NSUN5	NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (466 aa)
	MAVS	Mitochondrial antiviral signaling protein. (532 aa)
	RBM15	RNA binding motif protein 15. (1006 aa)
	VIRMA	Vir like m6A methyltransferase associated. (1812 aa)
	NPPA	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (152 aa)
	CDH5	Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (782 aa)
	FTO	FTO_NTD domain-containing protein. (509 aa)
	YTHDF3	YTH domain-containing family protein 3 isoform b. (588 aa)
	YTHDC2	YTH domain containing 2. (1430 aa)
	YTHDC1	YTH domain containing 1. (743 aa)
	NSUN4	NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (382 aa)
	ADARB1	Adenosine deaminase RNA specific B1. (702 aa)
	TTN	Uncharacterized protein. (563 aa)
	ADARB2	Adenosine deaminase RNA specific B2 (inactive). (734 aa)
	NSUN2	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (992 aa)
	ALYREF	Aly/REF export factor. (348 aa)
	ADA	Adenosine deaminase. (409 aa)
	YBX1	Y-box binding protein 1. (419 aa)
	METTL4	Methyltransferase like 4; Belongs to the MT-A70-like family. (478 aa)
	TRDMT1	tRNA aspartic acid methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (398 aa)
	NSUN6	NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (598 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (600 aa)
	NSUN3	NOP2/Sun RNA methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (339 aa)
	ADAR	Adenosine deaminase RNA specific. (1169 aa)
	HNRNPC	Heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1. (307 aa)
	IGF2BP2	Insulin like growth factor 2 mRNA binding protein 2. (592 aa)
	RBMX	RNA binding motif protein X-linked. (408 aa)
	ICAM1	Intercellular adhesion molecule 1. (537 aa)
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (652 aa)
	ATP2A2	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1042 aa)
	ALKBH5	AlkB homolog 5, RNA demethylase. (394 aa)
	NSUN7	NOP2/Sun RNA methyltransferase family member 7; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (724 aa)
	WTAP	Uncharacterized protein. (649 aa)
	METTL16	U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (561 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	IGF2BP3	Insulin-like growth factor 2 mRNA-binding protein 3. (586 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1023 aa)
	RAD52	RAD52 homolog, DNA repair protein. (406 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	DDX58	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...] (943 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	ADAR	ENSSSCP00000070139	ENSSSCP00000062912	Adenosine deaminase.	Adenosine deaminase RNA specific.	0.841
ADA	ADARB1	ENSSSCP00000070139	ENSSSCP00000057246	Adenosine deaminase.	Adenosine deaminase RNA specific B1.	0.492
ADA	ADARB2	ENSSSCP00000070139	ENSSSCP00000061813	Adenosine deaminase.	Adenosine deaminase RNA specific B2 (inactive).	0.674
ADAR	ADA	ENSSSCP00000062912	ENSSSCP00000070139	Adenosine deaminase RNA specific.	Adenosine deaminase.	0.841
ADAR	DDX58	ENSSSCP00000062912	ENSSSCP00000045260	Adenosine deaminase RNA specific.	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	0.600
ADAR	GRIA2	ENSSSCP00000062912	ENSSSCP00000045156	Adenosine deaminase RNA specific.	Glutamate ionotropic receptor AMPA type subunit 2.	0.500
ADAR	IFIH1	ENSSSCP00000062912	ENSSSCP00000044491	Adenosine deaminase RNA specific.	Interferon induced with helicase C domain 1.	0.521
ADARB1	ADA	ENSSSCP00000057246	ENSSSCP00000070139	Adenosine deaminase RNA specific B1.	Adenosine deaminase.	0.492
ADARB1	ALYREF	ENSSSCP00000057246	ENSSSCP00000071154	Adenosine deaminase RNA specific B1.	Aly/REF export factor.	0.588
ADARB1	GRIA2	ENSSSCP00000057246	ENSSSCP00000045156	Adenosine deaminase RNA specific B1.	Glutamate ionotropic receptor AMPA type subunit 2.	0.481
ADARB2	ADA	ENSSSCP00000061813	ENSSSCP00000070139	Adenosine deaminase RNA specific B2 (inactive).	Adenosine deaminase.	0.674
ADARB2	ALYREF	ENSSSCP00000061813	ENSSSCP00000071154	Adenosine deaminase RNA specific B2 (inactive).	Aly/REF export factor.	0.748
ADARB2	GRIA2	ENSSSCP00000061813	ENSSSCP00000045156	Adenosine deaminase RNA specific B2 (inactive).	Glutamate ionotropic receptor AMPA type subunit 2.	0.481
ALKBH5	FTO	ENSSSCP00000038766	ENSSSCP00000047110	AlkB homolog 5, RNA demethylase.	FTO_NTD domain-containing protein.	0.979
ALKBH5	HNRNPC	ENSSSCP00000038766	ENSSSCP00000024485	AlkB homolog 5, RNA demethylase.	Heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1.	0.758
ALKBH5	IGF2BP1	ENSSSCP00000038766	ENSSSCP00000020836	AlkB homolog 5, RNA demethylase.	Insulin-like growth factor 2 mRNA-binding protein 1 isoform X1.	0.672
ALKBH5	IGF2BP2	ENSSSCP00000038766	ENSSSCP00000028307	AlkB homolog 5, RNA demethylase.	Insulin like growth factor 2 mRNA binding protein 2.	0.675
ALKBH5	IGF2BP3	ENSSSCP00000038766	ENSSSCP00000044238	AlkB homolog 5, RNA demethylase.	Insulin-like growth factor 2 mRNA-binding protein 3.	0.685
ALKBH5	METTL16	ENSSSCP00000038766	ENSSSCP00000040541	AlkB homolog 5, RNA demethylase.	U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...]	0.731
ALKBH5	METTL4	ENSSSCP00000038766	ENSSSCP00000068190	AlkB homolog 5, RNA demethylase.	Methyltransferase like 4; Belongs to the MT-A70-like family.	0.678