STRINGSTRING
RBPJ RBPJ HDAC4 HDAC4 RUNX2 RUNX2 MYF5 MYF5 YTHDF2 YTHDF2 HDAC8 HDAC8 PAX7 PAX7 CCND1 CCND1 ZC3H13 ZC3H13 DGCR8 DGCR8 RBM15B RBM15B PPARG PPARG MYOD1 MYOD1 ANGPTL4 ANGPTL4 MEF2C MEF2C HGF HGF MSTN MSTN SHH SHH PAX3 PAX3 YTHDC2 YTHDC2 YTHDF3 YTHDF3 MYOG MYOG METTL14 METTL14 IGF2BP3 IGF2BP3 PDK3 PDK3 HNRNPA2B1 HNRNPA2B1 WTAP WTAP ALKBH5 ALKBH5 ACVR2A ACVR2A GADD45B GADD45B PPARGC1A PPARGC1A YTHDF1 YTHDF1 IGF2BP2 IGF2BP2 MEF2A MEF2A HDAC1 HDAC1 TBX2 TBX2 SRSF10 SRSF10 SRSF3 SRSF3 MYH1 MYH1 MTOR MTOR FOXO3 FOXO3 VIRMA VIRMA NOTCH2 NOTCH2 RBM15 RBM15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (491 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1160 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (253 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (600 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (441 aa)
PAX7Paired box 7. (521 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ZC3H13Zinc finger CCCH-type containing 13. (1640 aa)
DGCR8Microprocessor complex subunit DGCR8 isoform 1. (807 aa)
RBM15BRNA binding motif protein 15B. (854 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa)
MYOD1Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (319 aa)
ANGPTL4Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stre [...] (412 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
PAX3Paired box protein Pax-3 isoform PAX3e. (484 aa)
YTHDC2YTH domain containing 2. (1430 aa)
YTHDF3YTH domain-containing family protein 3 isoform b. (588 aa)
MYOGMyogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast dif [...] (215 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
IGF2BP3Insulin-like growth factor 2 mRNA-binding protein 3. (586 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
HNRNPA2B1Heterogeneous nuclear ribonucleoprotein A2/B1. (369 aa)
WTAPUncharacterized protein. (649 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
GADD45BGrowth arrest and DNA-damage-inducible, beta. (160 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (652 aa)
IGF2BP2Insulin like growth factor 2 mRNA binding protein 2. (592 aa)
MEF2AMyocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylate [...] (505 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa)
TBX2T-box 2 protein. (714 aa)
SRSF10Serine and arginine rich splicing factor 10. (261 aa)
SRSF3Serine and arginine rich splicing factor 3. (164 aa)
MYH1Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). (1956 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
FOXO3Forkhead box protein O3 isoform X1. (672 aa)
VIRMAVir like m6A methyltransferase associated. (1812 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
RBM15RNA binding motif protein 15. (1006 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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