STRINGSTRING
GLUL GLUL PECAM1 PECAM1 FLNA FLNA USH2A USH2A DOCK4 DOCK4 MSI1 MSI1 PCDH15 PCDH15 PDHB PDHB SLC17A7 SLC17A7 ARL13B ARL13B CIB2 CIB2 ITGAM ITGAM ANKS4B ANKS4B CDH23 CDH23 USH1C USH1C MYO7A MYO7A MYO7B MYO7B USH1G USH1G PXDN PXDN ITGB1 ITGB1 VIM VIM MSI2 MSI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GLULGlutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] (509 aa)
PECAM1Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa)
FLNAFilamin A. (2897 aa)
USH2AUncharacterized protein. (1544 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (1977 aa)
MSI1Musashi RNA binding protein 1. (436 aa)
PCDH15Uncharacterized protein. (984 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (361 aa)
SLC17A7Solute carrier family 17 member 7. (567 aa)
ARL13BADP ribosylation factor like GTPase 13B. (469 aa)
CIB2Calcium and integrin binding family member 2. (186 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1272 aa)
ANKS4BAnkyrin repeat and sterile alpha motif domain containing 4B. (417 aa)
CDH23Cadherin related 23. (3354 aa)
USH1CUSH1 protein network component harmonin. (858 aa)
MYO7AUnconventional myosin-VIIa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differenti [...] (2213 aa)
MYO7BMyosin VIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2140 aa)
USH1GUSH1 protein network component sans. (461 aa)
PXDNPeroxidasin. (1529 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (469 aa)
MSI2Musashi RNA binding protein 2. (354 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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