STRINGSTRING
KLF4 KLF4 CADM1 CADM1 ALYREF ALYREF A0A5G2QWB6_PIG A0A5G2QWB6_PIG METTL4 METTL4 NFATC4 NFATC4 YTHDF2 YTHDF2 ADAR ADAR NSUN2 NSUN2 NSUN4 NSUN4 YTHDC1 YTHDC1 YTHDC2 YTHDC2 FLNA FLNA FTO FTO METTL14 METTL14 IL1B IL1B CMTR2 CMTR2 ALKBH5 ALKBH5 YTHDF1 YTHDF1 TGFB1 TGFB1 ICAM1 ICAM1 FOXO1 FOXO1 TUT7 TUT7 METTL1 METTL1 NOP2 NOP2 ELP2 ELP2 CCL2 CCL2 IRF1 IRF1 DNMT1 DNMT1 NAT10 NAT10 DGCR8 DGCR8 TET2 TET2 IL1B2 IL1B2 VCAM1 VCAM1 CTSS CTSS VIRMA VIRMA MTO1 MTO1 TUT4 TUT4 CMTR1 CMTR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLF4Kruppel-like factor 4 isoform b. (510 aa)
CADM1Cell adhesion molecule 1. (473 aa)
ALYREFAly/REF export factor. (348 aa)
A0A5G2QWB6_PIGUncharacterized protein. (979 aa)
METTL4Methyltransferase like 4; Belongs to the MT-A70-like family. (478 aa)
NFATC4Nuclear factor of activated T cells 4. (937 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (600 aa)
ADARAdenosine deaminase RNA specific. (1169 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (992 aa)
NSUN4NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (382 aa)
YTHDC1YTH domain containing 1. (743 aa)
YTHDC2YTH domain containing 2. (1430 aa)
FLNAFilamin A. (2897 aa)
FTOFTO_NTD domain-containing protein. (509 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (267 aa)
CMTR2Cap methyltransferase 2. (764 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (652 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
ICAM1Intercellular adhesion molecule 1. (537 aa)
FOXO1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (662 aa)
TUT7Terminal uridylyl transferase 7. (1544 aa)
METTL1tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (277 aa)
NOP2SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (822 aa)
ELP2Elongator acetyltransferase complex subunit 2. (826 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
IRF1Interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] (320 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1706 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
DGCR8Microprocessor complex subunit DGCR8 isoform 1. (807 aa)
TET2Tet methylcytosine dioxygenase 2. (2019 aa)
IL1B2Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
VCAM1Uncharacterized protein. (537 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (341 aa)
VIRMAVir like m6A methyltransferase associated. (1812 aa)
MTO1Mitochondrial tRNA translation optimization 1. (691 aa)
TUT4Terminal uridylyl transferase 4. (1669 aa)
CMTR1Cap methyltransferase 1. (834 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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