26 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VIRMA	Vir like m6A methyltransferase associated. (1812 aa)
	RBM15	RNA binding motif protein 15. (1006 aa)
	ZC3H13	Zinc finger CCCH-type containing 13. (1640 aa)
	GNRH1	GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. (91 aa)
	CHD1	Chromodomain helicase DNA binding protein 1. (1691 aa)
	MSTN	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa)
	WT1	Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] (523 aa)
	IGF2BP1	Insulin-like growth factor 2 mRNA-binding protein 1 isoform X1. (577 aa)
	FGFR1	Fibroblast growth factor receptor. (820 aa)
	FGFR2	Fibroblast growth factor receptor. (820 aa)
	FGFR4	Fibroblast growth factor receptor. (903 aa)
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (652 aa)
	MYOM2	Uncharacterized protein. (888 aa)
	IRX5	Iroquois homeobox 5. (483 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (398 aa)
	ALKBH5	AlkB homolog 5, RNA demethylase. (394 aa)
	WTAP	Uncharacterized protein. (649 aa)
	FGFR3	Fibroblast growth factor receptor. (855 aa)
	DLX5	Homeobox protein DLX-5. (290 aa)
	METTL14	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
	FTO	FTO_NTD domain-containing protein. (509 aa)
	MYOG	Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast dif [...] (215 aa)
	MYLK2	Myosin light chain kinase 2. (652 aa)
	IRS1	Insulin receptor substrate 1. (1241 aa)
	PDK4	Protein-serine/threonine kinase. (411 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALKBH5	FTO	ENSSSCP00000038766	ENSSSCP00000047110	AlkB homolog 5, RNA demethylase.	FTO_NTD domain-containing protein.	0.979
ALKBH5	GAPDH	ENSSSCP00000038766	ENSSSCP00000035519	AlkB homolog 5, RNA demethylase.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.570
ALKBH5	IGF2BP1	ENSSSCP00000038766	ENSSSCP00000020836	AlkB homolog 5, RNA demethylase.	Insulin-like growth factor 2 mRNA-binding protein 1 isoform X1.	0.672
ALKBH5	METTL14	ENSSSCP00000038766	ENSSSCP00000046701	AlkB homolog 5, RNA demethylase.	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family.	0.953
ALKBH5	RBM15	ENSSSCP00000038766	ENSSSCP00000007262	AlkB homolog 5, RNA demethylase.	RNA binding motif protein 15.	0.853
ALKBH5	VIRMA	ENSSSCP00000038766	ENSSSCP00000006511	AlkB homolog 5, RNA demethylase.	Vir like m6A methyltransferase associated.	0.828
ALKBH5	WTAP	ENSSSCP00000038766	ENSSSCP00000039764	AlkB homolog 5, RNA demethylase.	Uncharacterized protein.	0.975
ALKBH5	YTHDF1	ENSSSCP00000038766	ENSSSCP00000031181	AlkB homolog 5, RNA demethylase.	YTH N6-methyladenosine RNA binding protein 1.	0.917
ALKBH5	ZC3H13	ENSSSCP00000038766	ENSSSCP00000010047	AlkB homolog 5, RNA demethylase.	Zinc finger CCCH-type containing 13.	0.855
FGFR1	FGFR2	ENSSSCP00000030160	ENSSSCP00000030305	Fibroblast growth factor receptor.	Fibroblast growth factor receptor.	0.923
FGFR1	FGFR4	ENSSSCP00000030160	ENSSSCP00000030615	Fibroblast growth factor receptor.	Fibroblast growth factor receptor.	0.953
FGFR1	GAPDH	ENSSSCP00000030160	ENSSSCP00000035519	Fibroblast growth factor receptor.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.568
FGFR1	IRS1	ENSSSCP00000030160	ENSSSCP00000061240	Fibroblast growth factor receptor.	Insulin receptor substrate 1.	0.706
FGFR1	MAPK1	ENSSSCP00000030160	ENSSSCP00000073842	Fibroblast growth factor receptor.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.465
FGFR2	FGFR1	ENSSSCP00000030305	ENSSSCP00000030160	Fibroblast growth factor receptor.	Fibroblast growth factor receptor.	0.923
FGFR2	FGFR3	ENSSSCP00000030305	ENSSSCP00000043155	Fibroblast growth factor receptor.	Fibroblast growth factor receptor.	0.482
FGFR2	FGFR4	ENSSSCP00000030305	ENSSSCP00000030615	Fibroblast growth factor receptor.	Fibroblast growth factor receptor.	0.923
FGFR2	GAPDH	ENSSSCP00000030305	ENSSSCP00000035519	Fibroblast growth factor receptor.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.457
FGFR2	IRS1	ENSSSCP00000030305	ENSSSCP00000061240	Fibroblast growth factor receptor.	Insulin receptor substrate 1.	0.682
FGFR3	FGFR2	ENSSSCP00000043155	ENSSSCP00000030305	Fibroblast growth factor receptor.	Fibroblast growth factor receptor.	0.482