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RHOA | Transforming protein RhoA isoform 1. (193 aa) | ||||
LMNA | Prelamin-A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. A [...] (704 aa) | ||||
MMP9 | Matrix metalloproteinase-9. (708 aa) | ||||
HCLS1 | Hematopoietic cell-specific Lyn substrate 1. (525 aa) | ||||
CTTN | Cortactin. (685 aa) | ||||
EGFR | Receptor protein-tyrosine kinase. (1205 aa) | ||||
CSF1 | Colony stimulating factor 1. (656 aa) | ||||
CDH1 | Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (925 aa) | ||||
SYNE2 | Spectrin repeat containing nuclear envelope protein 2. (6940 aa) | ||||
CFL2 | Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). (166 aa) | ||||
VCL | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa) | ||||
CD44 | CD44 molecule (Indian blood group). (767 aa) | ||||
MMP13 | Matrix metallopeptidase 13. (470 aa) | ||||
MMP14 | Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa) | ||||
EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa) | ||||
CFL1 | Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up- regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity). (179 aa) | ||||
SRC | Tyrosine-protein kinase. (559 aa) | ||||
FOXC2 | Forkhead box C2. (501 aa) |