24 items (Sus scrofa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Your Input:
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (652 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (381 aa)
	FUT2	Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (By similarity). Mediates interaction with intestinal microbiota influencing its composition (By similarity). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen, which is an essential substrate for the final step in the membrane-associated blood group antigen synthesis pathway (By similarity). (340 aa)
	GPR161	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (549 aa)
	STAT3	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
	WT1	Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] (523 aa)
	GGTA1P	N-acetyllactosaminide alpha-1,3-galactosyltransferase; Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isogloboside 3 (iGb3) (By similarity). (359 aa)
	PXDN	Peroxidasin. (1529 aa)
	CNOT1	CCR4-NOT transcription complex subunit 1. (2343 aa)
	JAK2	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
	JAK1	Tyrosine-protein kinase. (1154 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (398 aa)
	ALKBH5	AlkB homolog 5, RNA demethylase. (394 aa)
	WTAP	Uncharacterized protein. (649 aa)
	FUT2A	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (404 aa)
	FOXO6	Forkhead box O6. (685 aa)
	HSP90AA1	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (789 aa)
	METTL14	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
	FTO	FTO_NTD domain-containing protein. (509 aa)
	YTHDF3	YTH domain-containing family protein 3 isoform b. (588 aa)
	YTHDC1	YTH domain containing 1. (743 aa)
	SOCS3	Suppressor of cytokine signaling 3. (229 aa)
	TLR5	TIR domain-containing protein; Belongs to the Toll-like receptor family. (855 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (600 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALKBH5	FTO	ENSSSCP00000038766	ENSSSCP00000047110	AlkB homolog 5, RNA demethylase.	FTO_NTD domain-containing protein.	0.979
ALKBH5	GAPDH	ENSSSCP00000038766	ENSSSCP00000035519	AlkB homolog 5, RNA demethylase.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.570
ALKBH5	METTL14	ENSSSCP00000038766	ENSSSCP00000046701	AlkB homolog 5, RNA demethylase.	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family.	0.953
ALKBH5	WTAP	ENSSSCP00000038766	ENSSSCP00000039764	AlkB homolog 5, RNA demethylase.	Uncharacterized protein.	0.975
ALKBH5	YTHDC1	ENSSSCP00000038766	ENSSSCP00000049284	AlkB homolog 5, RNA demethylase.	YTH domain containing 1.	0.874
ALKBH5	YTHDF1	ENSSSCP00000038766	ENSSSCP00000031181	AlkB homolog 5, RNA demethylase.	YTH N6-methyladenosine RNA binding protein 1.	0.917
ALKBH5	YTHDF2	ENSSSCP00000038766	ENSSSCP00000065604	AlkB homolog 5, RNA demethylase.	YTH N6-methyladenosine RNA binding protein 2.	0.913
ALKBH5	YTHDF3	ENSSSCP00000038766	ENSSSCP00000048507	AlkB homolog 5, RNA demethylase.	YTH domain-containing family protein 3 isoform b.	0.890
CDK2	GAPDH	ENSSSCP00000000392	ENSSSCP00000035519	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.694
CDK2	HSP90AA1	ENSSSCP00000000392	ENSSSCP00000046159	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.456
CDK2	PXDN	ENSSSCP00000000392	ENSSSCP00000022033	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Peroxidasin.	0.628
CDK2	STAT3	ENSSSCP00000000392	ENSSSCP00000018439	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...]	0.590
CNOT1	YTHDF2	ENSSSCP00000023830	ENSSSCP00000065604	CCR4-NOT transcription complex subunit 1.	YTH N6-methyladenosine RNA binding protein 2.	0.486
FOXO6	STAT3	ENSSSCP00000043014	ENSSSCP00000018439	Forkhead box O6.	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...]	0.912
FTO	ALKBH5	ENSSSCP00000047110	ENSSSCP00000038766	FTO_NTD domain-containing protein.	AlkB homolog 5, RNA demethylase.	0.979
FTO	GAPDH	ENSSSCP00000047110	ENSSSCP00000035519	FTO_NTD domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.446
FTO	METTL14	ENSSSCP00000047110	ENSSSCP00000046701	FTO_NTD domain-containing protein.	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family.	0.905
FTO	WTAP	ENSSSCP00000047110	ENSSSCP00000039764	FTO_NTD domain-containing protein.	Uncharacterized protein.	0.912
FTO	YTHDC1	ENSSSCP00000047110	ENSSSCP00000049284	FTO_NTD domain-containing protein.	YTH domain containing 1.	0.830
FTO	YTHDF1	ENSSSCP00000047110	ENSSSCP00000031181	FTO_NTD domain-containing protein.	YTH N6-methyladenosine RNA binding protein 1.	0.871