25 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LUM	Lumican. (341 aa)
	FBLN5	Fibulin-5 isoform X2. (461 aa)
	COL10A1	Type X collagen. (675 aa)
	FBN1	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2871 aa)
	COL5A1	Fibrillar collagen NC1 domain-containing protein. (1918 aa)
	ASPN	Asporin. (370 aa)
	POSTN	Periostin. (836 aa)
	COL1A2	Fibrillar collagen NC1 domain-containing protein. (1135 aa)
	FN1	Fibronectin 1. (2462 aa)
	ECM1	Extracellular matrix protein 1. (559 aa)
	FGG	Fibrinogen gamma chain. (454 aa)
	TNXB	Uncharacterized protein. (4137 aa)
	ANXA2	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa)
	COL3A1	Collagen alpha-1(III) chain preproprotein. (1471 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
	COL2A1	Collagen type II alpha 1 chain. (1486 aa)
	LAMC1	Uncharacterized protein. (1607 aa)
	NID2	Nidogen 2. (1348 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (819 aa)
	OGN	Osteoglycin/mimecan. (298 aa)
	MFAP4	Microfibril associated protein 4. (304 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (381 aa)
	COL5A2	Collagen alpha-2(V) chain preproprotein. (1499 aa)
	COL1A1	Collagen type I alpha 1 chain. (1477 aa)
	MFAP2	Microfibril associated protein 2. (276 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ANXA2	ENSSSCP00000035521	ENSSSCP00000031749	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.	0.733
ACTB	COL1A1	ENSSSCP00000035521	ENSSSCP00000066291	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Collagen type I alpha 1 chain.	0.713
ACTB	COL1A2	ENSSSCP00000035521	ENSSSCP00000016253	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Fibrillar collagen NC1 domain-containing protein.	0.519
ACTB	COL2A1	ENSSSCP00000035521	ENSSSCP00000036099	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Collagen type II alpha 1 chain.	0.481
ACTB	COL3A1	ENSSSCP00000035521	ENSSSCP00000033771	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Collagen alpha-1(III) chain preproprotein.	0.503
ANXA2	ACTB	ENSSSCP00000031749	ENSSSCP00000035521	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.733
ASPN	COL1A1	ENSSSCP00000008621	ENSSSCP00000066291	Asporin.	Collagen type I alpha 1 chain.	0.483
ASPN	COL2A1	ENSSSCP00000008621	ENSSSCP00000036099	Asporin.	Collagen type II alpha 1 chain.	0.441
ASPN	COL3A1	ENSSSCP00000008621	ENSSSCP00000033771	Asporin.	Collagen alpha-1(III) chain preproprotein.	0.508
ASPN	FBN1	ENSSSCP00000008621	ENSSSCP00000005017	Asporin.	Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...]	0.471
ASPN	FGG	ENSSSCP00000008621	ENSSSCP00000024374	Asporin.	Fibrinogen gamma chain.	0.410
ASPN	LUM	ENSSSCP00000008621	ENSSSCP00000000978	Asporin.	Lumican.	0.536
ASPN	MFAP2	ENSSSCP00000008621	ENSSSCP00000066340	Asporin.	Microfibril associated protein 2.	0.454
ASPN	OGN	ENSSSCP00000008621	ENSSSCP00000045106	Asporin.	Osteoglycin/mimecan.	0.770
ASPN	POSTN	ENSSSCP00000008621	ENSSSCP00000009991	Asporin.	Periostin.	0.693
ASPN	PRELP	ENSSSCP00000008621	ENSSSCP00000051002	Asporin.	Proline and arginine rich end leucine rich repeat protein.	0.528
COL10A1	COL1A1	ENSSSCP00000004785	ENSSSCP00000066291	Type X collagen.	Collagen type I alpha 1 chain.	0.588
COL10A1	COL1A2	ENSSSCP00000004785	ENSSSCP00000016253	Type X collagen.	Fibrillar collagen NC1 domain-containing protein.	0.577
COL10A1	COL2A1	ENSSSCP00000004785	ENSSSCP00000036099	Type X collagen.	Collagen type II alpha 1 chain.	0.681
COL10A1	COL3A1	ENSSSCP00000004785	ENSSSCP00000033771	Type X collagen.	Collagen alpha-1(III) chain preproprotein.	0.551