9 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IQGAP1	IQ motif containing GTPase activating protein 1. (1709 aa)
	SRC	Tyrosine-protein kinase. (559 aa)
	CTSD	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. (408 aa)
	HCLS1	Hematopoietic cell-specific Lyn substrate 1. (525 aa)
	CTTN	Cortactin. (685 aa)
	PXN	Uncharacterized protein. (1072 aa)
	TLR5	TIR domain-containing protein; Belongs to the Toll-like receptor family. (855 aa)
	CLDN1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN1	IFNG	ENSSSCP00000037581	ENSSSCP00000036242	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.562
CTTN	IQGAP1	ENSSSCP00000069324	ENSSSCP00000001984	Cortactin.	IQ motif containing GTPase activating protein 1.	0.495
CTTN	PXN	ENSSSCP00000069324	ENSSSCP00000064760	Cortactin.	Uncharacterized protein.	0.903
CTTN	SRC	ENSSSCP00000069324	ENSSSCP00000029882	Cortactin.	Tyrosine-protein kinase.	0.842
HCLS1	PXN	ENSSSCP00000071142	ENSSSCP00000064760	Hematopoietic cell-specific Lyn substrate 1.	Uncharacterized protein.	0.882
HCLS1	SRC	ENSSSCP00000071142	ENSSSCP00000029882	Hematopoietic cell-specific Lyn substrate 1.	Tyrosine-protein kinase.	0.981
IFNG	CLDN1	ENSSSCP00000036242	ENSSSCP00000037581	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.562
IFNG	SRC	ENSSSCP00000036242	ENSSSCP00000029882	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	Tyrosine-protein kinase.	0.567
IFNG	TLR5	ENSSSCP00000036242	ENSSSCP00000061007	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.628
IQGAP1	CTTN	ENSSSCP00000001984	ENSSSCP00000069324	IQ motif containing GTPase activating protein 1.	Cortactin.	0.495
IQGAP1	PXN	ENSSSCP00000001984	ENSSSCP00000064760	IQ motif containing GTPase activating protein 1.	Uncharacterized protein.	0.401
IQGAP1	SRC	ENSSSCP00000001984	ENSSSCP00000029882	IQ motif containing GTPase activating protein 1.	Tyrosine-protein kinase.	0.589
PXN	CTTN	ENSSSCP00000064760	ENSSSCP00000069324	Uncharacterized protein.	Cortactin.	0.903
PXN	HCLS1	ENSSSCP00000064760	ENSSSCP00000071142	Uncharacterized protein.	Hematopoietic cell-specific Lyn substrate 1.	0.882
PXN	IQGAP1	ENSSSCP00000064760	ENSSSCP00000001984	Uncharacterized protein.	IQ motif containing GTPase activating protein 1.	0.401
PXN	SRC	ENSSSCP00000064760	ENSSSCP00000029882	Uncharacterized protein.	Tyrosine-protein kinase.	0.996
SRC	CTTN	ENSSSCP00000029882	ENSSSCP00000069324	Tyrosine-protein kinase.	Cortactin.	0.842
SRC	HCLS1	ENSSSCP00000029882	ENSSSCP00000071142	Tyrosine-protein kinase.	Hematopoietic cell-specific Lyn substrate 1.	0.981
SRC	IFNG	ENSSSCP00000029882	ENSSSCP00000036242	Tyrosine-protein kinase.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.567
SRC	IQGAP1	ENSSSCP00000029882	ENSSSCP00000001984	Tyrosine-protein kinase.	IQ motif containing GTPase activating protein 1.	0.589