STRINGSTRING
COL10A1 COL10A1 SPP1 SPP1 CHODL CHODL LOX LOX FMOD FMOD COL1A2 COL1A2 P3H1 P3H1 COL6A2 COL6A2 IBSP IBSP GYPA GYPA ENG ENG COL3A1 COL3A1 COL2A1 COL2A1 CD200 CD200 CRLF1 CRLF1 PECAM1 PECAM1 COL5A1 COL5A1 ITGB5 ITGB5 P4HA2 P4HA2 COL5A2 COL5A2 NGF NGF PTK2 PTK2 PAX7 PAX7 MYF5 MYF5 COL1A1 COL1A1 RUNX2 RUNX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL10A1Type X collagen. (675 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (303 aa)
CHODLChondrolectin. (272 aa)
LOXProtein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). (376 aa)
COL1A2Fibrillar collagen NC1 domain-containing protein. (1135 aa)
P3H1Prolyl 3-hydroxylase 1 isoform 1. (698 aa)
COL6A2Collagen type VI alpha 2 chain. (943 aa)
IBSPBone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. (316 aa)
GYPAGlycophorin-A; Glycophorin A is the major intrinsic membrane sialoglycoprotein of the erythrocyte. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane (By similarity). (164 aa)
ENGEndoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
CD200OX-2 membrane glycoprotein isoform X2. (301 aa)
CRLF1Cytokine receptor like factor 1. (421 aa)
PECAM1Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
P4HA2Prolyl 4-hydroxylase subunit alpha 2. (555 aa)
COL5A2Collagen alpha-2(V) chain preproprotein. (1499 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (385 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1119 aa)
PAX7Paired box 7. (521 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (253 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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