5 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IFNB1	Interferon-beta-1. (186 aa)
	IFNAR2	Uncharacterized protein. (574 aa)
	JAK1	Tyrosine-protein kinase. (1154 aa)
	TYK2	Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1226 aa)
	IFNAR1	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). (617 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IFNAR1	IFNAR2	ENSSSCP00000067427	ENSSSCP00000031430	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Uncharacterized protein.	0.998
IFNAR1	IFNB1	ENSSSCP00000067427	ENSSSCP00000005550	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Interferon-beta-1.	0.997
IFNAR1	JAK1	ENSSSCP00000067427	ENSSSCP00000032415	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Tyrosine-protein kinase.	0.995
IFNAR1	TYK2	ENSSSCP00000067427	ENSSSCP00000035640	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.993
IFNAR2	IFNAR1	ENSSSCP00000031430	ENSSSCP00000067427	Uncharacterized protein.	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	0.998
IFNAR2	IFNB1	ENSSSCP00000031430	ENSSSCP00000005550	Uncharacterized protein.	Interferon-beta-1.	0.892
IFNAR2	JAK1	ENSSSCP00000031430	ENSSSCP00000032415	Uncharacterized protein.	Tyrosine-protein kinase.	0.970
IFNAR2	TYK2	ENSSSCP00000031430	ENSSSCP00000035640	Uncharacterized protein.	Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.880
IFNB1	IFNAR1	ENSSSCP00000005550	ENSSSCP00000067427	Interferon-beta-1.	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	0.997
IFNB1	IFNAR2	ENSSSCP00000005550	ENSSSCP00000031430	Interferon-beta-1.	Uncharacterized protein.	0.892
IFNB1	JAK1	ENSSSCP00000005550	ENSSSCP00000032415	Interferon-beta-1.	Tyrosine-protein kinase.	0.894
IFNB1	TYK2	ENSSSCP00000005550	ENSSSCP00000035640	Interferon-beta-1.	Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.866
JAK1	IFNAR1	ENSSSCP00000032415	ENSSSCP00000067427	Tyrosine-protein kinase.	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	0.995
JAK1	IFNAR2	ENSSSCP00000032415	ENSSSCP00000031430	Tyrosine-protein kinase.	Uncharacterized protein.	0.970
JAK1	IFNB1	ENSSSCP00000032415	ENSSSCP00000005550	Tyrosine-protein kinase.	Interferon-beta-1.	0.894
JAK1	TYK2	ENSSSCP00000032415	ENSSSCP00000035640	Tyrosine-protein kinase.	Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.954
TYK2	IFNAR1	ENSSSCP00000035640	ENSSSCP00000067427	Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).	0.993
TYK2	IFNAR2	ENSSSCP00000035640	ENSSSCP00000031430	Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Uncharacterized protein.	0.880
TYK2	IFNB1	ENSSSCP00000035640	ENSSSCP00000005550	Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Interferon-beta-1.	0.866
TYK2	JAK1	ENSSSCP00000035640	ENSSSCP00000032415	Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Tyrosine-protein kinase.	0.954