STRINGSTRING
ADAM19 ADAM19 GFAP GFAP WT1 WT1 ASH2L ASH2L HNRNPC HNRNPC NES NES YTHDF1 YTHDF1 OLIG2 OLIG2 PAX6 PAX6 GAPDH GAPDH SOX10 SOX10 ALDH1L1 ALDH1L1 ETS2 ETS2 ALKBH5 ALKBH5 WTAP WTAP HNRNPA2B1 HNRNPA2B1 NUBP2 NUBP2 METTL14 METTL14 FTO FTO SPOCK2 SPOCK2 TUBB2B TUBB2B YTHDC1 YTHDC1 RBBP5 RBBP5 MEN1 MEN1 ZC3H13 ZC3H13 RBM15 RBM15 VIRMA VIRMA CDKN2B CDKN2B PRRC2A PRRC2A WDR5 WDR5 YTHDF2 YTHDF2 SVIL SVIL MDM2 MDM2 TP53 TP53 KLF9 KLF9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADAM19ADAM metallopeptidase domain 19. (951 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (468 aa)
WT1Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] (523 aa)
ASH2LASH2 like, histone lysine methyltransferase complex subunit. (635 aa)
HNRNPCHeterogeneous nuclear ribonucleoproteins C1/C2 isoform X1. (307 aa)
NESNestin; Belongs to the intermediate filament family. (1699 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (652 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
PAX6Paired box 6. (498 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (398 aa)
SOX10Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (867 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (470 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
WTAPUncharacterized protein. (649 aa)
HNRNPA2B1Heterogeneous nuclear ribonucleoprotein A2/B1. (369 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (325 aa)
METTL14N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
FTOFTO_NTD domain-containing protein. (509 aa)
SPOCK2SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (424 aa)
TUBB2BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (465 aa)
YTHDC1YTH domain containing 1. (743 aa)
RBBP5RB binding protein 5, histone lysine methyltransferase complex subunit. (517 aa)
MEN1Menin 1. (704 aa)
ZC3H13Zinc finger CCCH-type containing 13. (1640 aa)
RBM15RNA binding motif protein 15. (1006 aa)
VIRMAVir like m6A methyltransferase associated. (1812 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
PRRC2ABAT2_N domain-containing protein. (2166 aa)
WDR5WD repeat domain 5. (389 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (600 aa)
SVILSupervillin. (2229 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (496 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
KLF9Krueppel-like factor 9; Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation; Belongs to the Sp1 C2H2-type zinc-finger protein family. (334 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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