39 items (Sus scrofa) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	EGR2	E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. (471 aa)
	OAS2	2'-5'-oligoadenylate synthetase 2. (713 aa)
	TBX3	T-box transcription factor TBX3 isoform 2. (745 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
	RIPOR2	PL48 domain-containing protein. (1063 aa)
	PPARA	Uncharacterized protein. (469 aa)
	FOS	Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (440 aa)
	IFIT1	Interferon-stimulated protein 60. (509 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (732 aa)
	KLHL40	Kelch like family member 40. (623 aa)
	PLIN4	Perilipin 4. (1655 aa)
	ASNS	Asparagine synthetase [glutamine-hydrolyzing]. (545 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (619 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
	SH3BP5	SH3 domain binding protein 5. (452 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa)
	G0S2	G0/G1 switch 2 protein. (103 aa)
	PPARGC1A	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa)
	STAT1	Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa)
	HOMER1	Homer scaffold protein 1. (365 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (398 aa)
	IFI44	G domain-containing protein. (438 aa)
	GBP1	GB1/RHD3-type G domain-containing protein. (614 aa)
	CPT1B	Carnitine O-palmitoyltransferase 1, muscle isoform. (807 aa)
	RHOA	Transforming protein RhoA isoform 1. (193 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2383 aa)
	UCP3	Mitochondrial uncoupling protein 3; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. (310 aa)
	PARP9	Poly(ADP-ribose) polymerase family member 9. (847 aa)
	IRS2	Insulin receptor substrate 2. (1092 aa)
	PLEC	Plectin. (5422 aa)
	CARNS1	Carnosine synthase 1 isoform 1. (951 aa)
	SLC27A5	Solute carrier family 27 member 5. (710 aa)
	ACSL4	Acyl-CoA synthetase long chain family member 4. (711 aa)
	RXRG	Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (463 aa)
	MEGF10	Uncharacterized protein. (368 aa)
	IRF9	IRF tryptophan pentad repeat domain-containing protein. (418 aa)
	PLIN5	Perilipin 5. (736 aa)
	OAS1	2'-5'-oligoadenylate synthase 1. (334 aa)
	DDX60	Putative ATP-dependent RNA helicase DDX60 isoform X1. (1704 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACSL4	ENSSSCP00000047454	ENSSSCP00000056573	Acetyl-CoA carboxylase alpha.	Acyl-CoA synthetase long chain family member 4.	0.508
ACACA	CPT1B	ENSSSCP00000047454	ENSSSCP00000044392	Acetyl-CoA carboxylase alpha.	Carnitine O-palmitoyltransferase 1, muscle isoform.	0.597
ACACA	GAPDH	ENSSSCP00000047454	ENSSSCP00000035519	Acetyl-CoA carboxylase alpha.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.497
ACACA	PPARA	ENSSSCP00000047454	ENSSSCP00000000007	Acetyl-CoA carboxylase alpha.	Uncharacterized protein.	0.658
ACACA	PPARGC1A	ENSSSCP00000047454	ENSSSCP00000032437	Acetyl-CoA carboxylase alpha.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...]	0.563
ACACA	PRKAG2	ENSSSCP00000047454	ENSSSCP00000017412	Acetyl-CoA carboxylase alpha.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.912
ACSL4	ACACA	ENSSSCP00000056573	ENSSSCP00000047454	Acyl-CoA synthetase long chain family member 4.	Acetyl-CoA carboxylase alpha.	0.508
ACSL4	CPT1B	ENSSSCP00000056573	ENSSSCP00000044392	Acyl-CoA synthetase long chain family member 4.	Carnitine O-palmitoyltransferase 1, muscle isoform.	0.928
ACSL4	GAPDH	ENSSSCP00000056573	ENSSSCP00000035519	Acyl-CoA synthetase long chain family member 4.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.417
ACSL4	PLIN4	ENSSSCP00000056573	ENSSSCP00000014361	Acyl-CoA synthetase long chain family member 4.	Perilipin 4.	0.427
ACSL4	PPARA	ENSSSCP00000056573	ENSSSCP00000000007	Acyl-CoA synthetase long chain family member 4.	Uncharacterized protein.	0.655
ASNS	SH3BP5	ENSSSCP00000016267	ENSSSCP00000024104	Asparagine synthetase [glutamine-hydrolyzing].	SH3 domain binding protein 5.	0.426
CARNS1	G0S2	ENSSSCP00000053150	ENSSSCP00000031119	Carnosine synthase 1 isoform 1.	G0/G1 switch 2 protein.	0.424
CARNS1	SH3BP5	ENSSSCP00000053150	ENSSSCP00000024104	Carnosine synthase 1 isoform 1.	SH3 domain binding protein 5.	0.680
CPT1B	ACACA	ENSSSCP00000044392	ENSSSCP00000047454	Carnitine O-palmitoyltransferase 1, muscle isoform.	Acetyl-CoA carboxylase alpha.	0.597
CPT1B	ACSL4	ENSSSCP00000044392	ENSSSCP00000056573	Carnitine O-palmitoyltransferase 1, muscle isoform.	Acyl-CoA synthetase long chain family member 4.	0.928
CPT1B	PPARA	ENSSSCP00000044392	ENSSSCP00000000007	Carnitine O-palmitoyltransferase 1, muscle isoform.	Uncharacterized protein.	0.628
CPT1B	PPARGC1A	ENSSSCP00000044392	ENSSSCP00000032437	Carnitine O-palmitoyltransferase 1, muscle isoform.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...]	0.706
CPT1B	UCP3	ENSSSCP00000044392	ENSSSCP00000049969	Carnitine O-palmitoyltransferase 1, muscle isoform.	Mitochondrial uncoupling protein 3; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.640
DDX60	IFI44	ENSSSCP00000066827	ENSSSCP00000036739	Putative ATP-dependent RNA helicase DDX60 isoform X1.	G domain-containing protein.	0.678