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COL5A1 COL5A1 USP3 USP3 COL6A6 COL6A6 CKM CKM UTRN UTRN COL1A1 COL1A1 COL6A1 COL6A1 FERMT2 FERMT2 COL4A1 COL4A1 CMAH CMAH ANXA8 ANXA8 CILP CILP COL6A5 COL6A5 COL5A2 COL5A2 DAG1 DAG1 FKRP FKRP PRELP PRELP MFAP4 MFAP4 DTNA DTNA ANXA13 ANXA13 LAMC1 LAMC1 DPT DPT SERPINH1 SERPINH1 CKMT2 CKMT2 ANXA2 ANXA2 COL18A1 COL18A1 ANXA11 ANXA11 BGN BGN CTSB CTSB FGG FGG ANXA7 ANXA7 SSPN SSPN VTN VTN THBS4 THBS4 ANXA6 ANXA6 COL4A3 COL4A3 LAMB1 LAMB1 COL1A2 COL1A2 FMOD FMOD TGFBI TGFBI CKB CKB CILP2 CILP2 COMP COMP MTR MTR COL4A2 COL4A2 POSTN POSTN ANXA5 ANXA5 FGA FGA FGB FGB ASPN ASPN ANXA9 ANXA9 COL15A1 COL15A1 THBS1 THBS1 CKMT1A CKMT1A FBN1 FBN1 COL12A1 COL12A1 FBLN5 FBLN5 LUM LUM DCN DCN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
USP3Ubiquitinyl hydrolase 1. (540 aa)
COL6A6Collagen type VI alpha 6 chain. (2266 aa)
CKMCreatine kinase M-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). (380 aa)
UTRNUncharacterized protein. (3433 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
COL6A1Collagen type VI alpha 1 chain. (1028 aa)
FERMT2Fermitin family member 2. (776 aa)
COL4A1Collagen IV NC1 domain-containing protein. (461 aa)
CMAHCytidine monophosphate-N-acetylneuraminic acid hydroxylase; Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell- pathogen interactions. Catalyzes the conversion of CMP-N- acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. (596 aa)
ANXA8Annexin. (354 aa)
CILPCartilage intermediate layer protein 1 C2; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity). (1193 aa)
COL6A5Collagen type VI alpha 5 chain. (2337 aa)
COL5A2Collagen alpha-2(V) chain preproprotein. (1499 aa)
DAG1Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] (912 aa)
FKRPFukutin related protein. (495 aa)
PRELPProline and arginine rich end leucine rich repeat protein. (381 aa)
MFAP4Microfibril associated protein 4. (304 aa)
DTNADystrobrevin. (725 aa)
ANXA13Annexin. (357 aa)
LAMC1Uncharacterized protein. (1607 aa)
DPTDermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation (By similarity). Accelerates collagen fibril formation, and stabilizes collagen fibrils against low- temperature dissociation. (201 aa)
SERPINH1SERPIN domain-containing protein; Belongs to the serpin family. (418 aa)
CKMT2Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family. (443 aa)
ANXA2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa)
COL18A1Collagen type XVIII alpha 1 chain. (1755 aa)
ANXA11Annexin. (516 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (338 aa)
CTSBCathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). (416 aa)
FGGFibrinogen gamma chain. (454 aa)
ANXA7Annexin. (485 aa)
SSPNSarcospan. (243 aa)
VTNVitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). (523 aa)
THBS4Thrombospondin 4. (976 aa)
ANXA6Annexin. (672 aa)
COL4A3Collagen type IV alpha 3 chain. (1669 aa)
LAMB1Laminin subunit beta 1. (1785 aa)
COL1A2Fibrillar collagen NC1 domain-containing protein. (1135 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). (376 aa)
TGFBITransforming growth factor-beta-induced protein ig-h3; Plays a role in cell adhesion (By similarity). May play a role in cell-collagen interactions. (709 aa)
CKBCreatine kinase B-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. (403 aa)
CILP2Cartilage intermediate layer protein 2. (1163 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1265 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
POSTNPeriostin. (836 aa)
ANXA5Annexin. (321 aa)
FGAFibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] (924 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (534 aa)
ASPNAsporin. (370 aa)
ANXA9Annexin. (360 aa)
COL15A1Collagen type XV alpha 1 chain. (1359 aa)
THBS1Uncharacterized protein. (1170 aa)
CKMT1ACreatine kinase U-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). (416 aa)
FBN1Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2871 aa)
COL12A1Collagen type XII alpha 1 chain. (3065 aa)
FBLN5Fibulin-5 isoform X2. (461 aa)
LUMLumican. (341 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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