node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGPAT1 | GPAT2 | ENSSSCP00000029658 | ENSSSCP00000025922 | PlsC domain-containing protein. | PlsC domain-containing protein. | 0.863 |
AGPAT1 | GPAT4 | ENSSSCP00000029658 | ENSSSCP00000007481 | PlsC domain-containing protein. | PlsC domain-containing protein. | 0.940 |
AGPAT1 | PLD1 | ENSSSCP00000029658 | ENSSSCP00000037066 | PlsC domain-containing protein. | Phospholipase. | 0.928 |
AGPAT1 | PLD2 | ENSSSCP00000029658 | ENSSSCP00000018976 | PlsC domain-containing protein. | Phospholipase. | 0.928 |
AGPAT1 | PLPP2 | ENSSSCP00000029658 | ENSSSCP00000064443 | PlsC domain-containing protein. | Phospholipid phosphatase 2. | 0.938 |
ATG5 | GAPDH | ENSSSCP00000071330 | ENSSSCP00000035519 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.690 |
GAPDH | ATG5 | ENSSSCP00000035519 | ENSSSCP00000071330 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] | 0.690 |
GAPDH | ISG15 | ENSSSCP00000035519 | ENSSSCP00000041015 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Ubiquitin-like modifier. | 0.659 |
GAPDH | PFKP | ENSSSCP00000035519 | ENSSSCP00000011907 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. | 0.723 |
GAPDH | TIGAR | ENSSSCP00000035519 | ENSSSCP00000021128 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | TP53 induced glycolysis regulatory phosphatase. | 0.531 |
GAPDH | TIMP2 | ENSSSCP00000035519 | ENSSSCP00000067249 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | Uncharacterized protein. | 0.597 |
GPAT2 | AGPAT1 | ENSSSCP00000025922 | ENSSSCP00000029658 | PlsC domain-containing protein. | PlsC domain-containing protein. | 0.863 |
GPAT2 | GPAT4 | ENSSSCP00000025922 | ENSSSCP00000007481 | PlsC domain-containing protein. | PlsC domain-containing protein. | 0.965 |
GPAT4 | AGPAT1 | ENSSSCP00000007481 | ENSSSCP00000029658 | PlsC domain-containing protein. | PlsC domain-containing protein. | 0.940 |
GPAT4 | GPAT2 | ENSSSCP00000007481 | ENSSSCP00000025922 | PlsC domain-containing protein. | PlsC domain-containing protein. | 0.965 |
ISG15 | GAPDH | ENSSSCP00000041015 | ENSSSCP00000035519 | Ubiquitin-like modifier. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.659 |
PFKP | GAPDH | ENSSSCP00000011907 | ENSSSCP00000035519 | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.723 |
PFKP | TIGAR | ENSSSCP00000011907 | ENSSSCP00000021128 | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. | TP53 induced glycolysis regulatory phosphatase. | 0.569 |
PLD1 | AGPAT1 | ENSSSCP00000037066 | ENSSSCP00000029658 | Phospholipase. | PlsC domain-containing protein. | 0.928 |
PLD1 | PLD2 | ENSSSCP00000037066 | ENSSSCP00000018976 | Phospholipase. | Phospholipase. | 0.904 |