28 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACE	Angiotensin-converting enzyme. (1309 aa)
	MUC1	SEA domain-containing protein. (638 aa)
	AMY2	Pancreatic alpha-amylase. (511 aa)
	LOC100153854	Alpha-amylase. (498 aa)
	PFN4	Profilin; Belongs to the profilin family. (129 aa)
	GHRL	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (118 aa)
	MUC13	Uncharacterized protein. (537 aa)
	MUC15	Mucin 15, cell surface associated. (333 aa)
	GCG	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
	PFN1	Profilin; Belongs to the profilin family. (212 aa)
	PFN2	Profilin; Belongs to the profilin family. (189 aa)
	GAST	Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. (104 aa)
	LOC110258046	Alpha-amylase. (415 aa)
	LOC100621820	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (263 aa)
	GIP	Gastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion; Belongs to the glucagon family. (144 aa)
	CTRB2	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (264 aa)
	I3LLP2_PIG	Alpha-amylase. (510 aa)
	LTF	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-\|- and -Arg-Arg-Ser-Arg-\|-, and of Z-Phe-Arg-\|-aminomethylcoumarin sites. (704 aa)
	LOC100153446	Alpha-amylase. (500 aa)
	ACE2	Angiotensin-converting enzyme. (805 aa)
	PVALB	Parvalbumin alpha; Belongs to the parvalbumin family. (141 aa)
	A0A287AXW5_PIG	Profilin; Belongs to the profilin family. (129 aa)
	LOC100739735	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (290 aa)
	SST	Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. (116 aa)
	LOC100153783	Ovalbumin isoform X1; Belongs to the serpin family. (385 aa)
	DPP4	Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (833 aa)
	TG	Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling. Following TG re-internalization and lysosomal- mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity); Belongs to the type-B carboxylesterase/lipase family. (2727 aa)
	ATP4A	Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. (1041 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ACE2	ENSSSCP00000018326	ENSSSCP00000028755	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.571
ACE	ATP4A	ENSSSCP00000018326	ENSSSCP00000069966	Angiotensin-converting enzyme.	Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.	0.459
ACE	CTRB2	ENSSSCP00000018326	ENSSSCP00000024109	Angiotensin-converting enzyme.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.577
ACE	DPP4	ENSSSCP00000018326	ENSSSCP00000059750	Angiotensin-converting enzyme.	Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...]	0.818
ACE	GCG	ENSSSCP00000018326	ENSSSCP00000016844	Angiotensin-converting enzyme.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...]	0.598
ACE	LOC100621820	ENSSSCP00000018326	ENSSSCP00000023533	Angiotensin-converting enzyme.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.769
ACE	LOC100739735	ENSSSCP00000018326	ENSSSCP00000051113	Angiotensin-converting enzyme.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.663
ACE	LTF	ENSSSCP00000018326	ENSSSCP00000026769	Angiotensin-converting enzyme.	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-\|- and -Arg-Arg-Ser-Arg-\|-, and of Z-Phe-Arg-\|-aminomethylcoumarin sites.	0.542
ACE2	ACE	ENSSSCP00000028755	ENSSSCP00000018326	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.571
ACE2	CTRB2	ENSSSCP00000028755	ENSSSCP00000024109	Angiotensin-converting enzyme.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.492
ACE2	DPP4	ENSSSCP00000028755	ENSSSCP00000059750	Angiotensin-converting enzyme.	Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...]	0.996
ACE2	GCG	ENSSSCP00000028755	ENSSSCP00000016844	Angiotensin-converting enzyme.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...]	0.471
ACE2	GHRL	ENSSSCP00000028755	ENSSSCP00000012327	Angiotensin-converting enzyme.	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	0.512
ACE2	LOC100621820	ENSSSCP00000028755	ENSSSCP00000023533	Angiotensin-converting enzyme.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.493
ACE2	LOC100739735	ENSSSCP00000028755	ENSSSCP00000051113	Angiotensin-converting enzyme.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.493
AMY2	CTRB2	ENSSSCP00000007308	ENSSSCP00000024109	Pancreatic alpha-amylase.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.782
AMY2	DPP4	ENSSSCP00000007308	ENSSSCP00000059750	Pancreatic alpha-amylase.	Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...]	0.419
AMY2	GCG	ENSSSCP00000007308	ENSSSCP00000016844	Pancreatic alpha-amylase.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...]	0.577
AMY2	GHRL	ENSSSCP00000007308	ENSSSCP00000012327	Pancreatic alpha-amylase.	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	0.436
AMY2	I3LLP2_PIG	ENSSSCP00000007308	ENSSSCP00000025012	Pancreatic alpha-amylase.	Alpha-amylase.	0.405