STRINGSTRING
EIF2AK2 EIF2AK2 FUT2 FUT2 SLC35A1 SLC35A1 IFNE IFNE GALNT12 GALNT12 MUC1 MUC1 MAVS MAVS MUC13 MUC13 RENBP RENBP ST3GAL4 ST3GAL4 ST6GALNAC1 ST6GALNAC1 STAT6 STAT6 STAT4 STAT4 ILK ILK GALNT5 GALNT5 F3 F3 AHR AHR IRF3 IRF3 MX1 MX1 GALNT3 GALNT3 STAT1 STAT1 MUC20 MUC20 BRCA1 BRCA1 B3GNT3 B3GNT3 EDN1 EDN1 MUC5AC MUC5AC GALNT15 GALNT15 MUC4 MUC4 GALNT11 GALNT11 NAGK NAGK ALG14 ALG14 MX2 MX2 DDX5 DDX5 ALG13 ALG13 IRF9 IRF9 GCNT1 GCNT1 FUT1 FUT1 GALNT4 GALNT4 OAS1 OAS1 STAT2 STAT2 C1GALT1 C1GALT1 GCNT3 GCNT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (546 aa)
FUT2Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (By similarity). Mediates interaction with intestinal microbiota influencing its composition (By similarity). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen, which is an essential substrate for the final step in the membrane-associated blood group antigen synthesis pathway (By similarity). (340 aa)
SLC35A1Solute carrier family 35 member A1. (334 aa)
IFNEInterferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. (193 aa)
GALNT12Polypeptide N-acetylgalactosaminyltransferase. (597 aa)
MUC1SEA domain-containing protein. (638 aa)
MAVSMitochondrial antiviral signaling protein. (532 aa)
MUC13Uncharacterized protein. (537 aa)
RENBPN-acylglucosamine 2-epimerase; Catalyzes the interconversion of N-acetylglucosamine to N- acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway; Belongs to the N-acylglucosamine 2-epimerase family. (450 aa)
ST3GAL4CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 4; Belongs to the glycosyltransferase 29 family. (393 aa)
ST6GALNAC1ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (591 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
ILKIntegrin linked kinase. (479 aa)
GALNT5Polypeptide N-acetylgalactosaminyltransferase. (940 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
AHRAryl hydrocarbon receptor. (849 aa)
IRF3Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...] (452 aa)
MX1Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against influenza A virus, (IAV). Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. (650 aa)
GALNT3Polypeptide N-acetylgalactosaminyltransferase. (633 aa)
STAT1Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa)
MUC20Uncharacterized protein. (599 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1865 aa)
B3GNT3Hexosyltransferase. (374 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
MUC5ACUncharacterized protein. (3330 aa)
GALNT15Polypeptide N-acetylgalactosaminyltransferase. (635 aa)
MUC4Uncharacterized protein. (1173 aa)
GALNT11Polypeptide N-acetylgalactosaminyltransferase. (608 aa)
NAGKN-acetylglucosamine kinase. (402 aa)
ALG14UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform 1. (216 aa)
MX2Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against influenza virus A (FLUAV). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (711 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa)
ALG13Uncharacterized protein. (522 aa)
IRF9IRF tryptophan pentad repeat domain-containing protein. (418 aa)
GCNT1Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase. (428 aa)
FUT1Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. (364 aa)
GALNT4Polypeptide N-acetylgalactosaminyltransferase. (582 aa)
OAS12'-5'-oligoadenylate synthase 1. (334 aa)
STAT2Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] (900 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (367 aa)
GCNT3Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3. (440 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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