STRINGSTRING
TNMD TNMD OSTN OSTN FDFT1 FDFT1 SMAD5 SMAD5 BGN BGN MKX MKX PXDN PXDN FASN FASN THBS4 THBS4 SOX9 SOX9 FMOD FMOD EGR1 EGR1 NOG NOG PPARG PPARG CCK CCK EGR2 EGR2 BMP7 BMP7 PDPN PDPN RUNX2 RUNX2 NFATC4 NFATC4 COL1A1 COL1A1 ALPL ALPL ALB ALB SCX SCX SP7 SP7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNMDTenomodulin. (317 aa)
OSTNMusclin. (132 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (417 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (338 aa)
MKXMohawk homeobox. (351 aa)
PXDNPeroxidasin. (1529 aa)
FASNUncharacterized protein. (1430 aa)
THBS4Thrombospondin 4. (976 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). (376 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa)
CCKCholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. (154 aa)
EGR2E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. (471 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
PDPNUncharacterized protein. (159 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
NFATC4Nuclear factor of activated T cells 4. (937 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
ALPLAlkaline phosphatase. (834 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (659 aa)
SCXBasic helix-loop-helix transcription factor scleraxis. (310 aa)
SP7Sp7 transcription factor. (432 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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