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CYP2B22 CYP2B22 VIP VIP SAL1 SAL1 PTGES PTGES GK GK PLPP1 PLPP1 FASN FASN CYP4F8 CYP4F8 PSPH PSPH SHMT1 SHMT1 MGLL MGLL PTGS2 PTGS2 ELOVL6 ELOVL6 HACD2 HACD2 GPX1 GPX1 GPX3 GPX3 ACACA ACACA DGAT2 DGAT2 DGKB DGKB SHMT2 SHMT2 LEP LEP PLA2G4A PLA2G4A GGT5 GGT5 G6PD G6PD TNF TNF PHGDH PHGDH SDS SDS PLPP2 PLPP2 CBR4 CBR4 PLPP3 PLPP3 LPIN1 LPIN1 LOC110256000 LOC110256000 SCD SCD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
CYP2B22Uncharacterized protein; Belongs to the cytochrome P450 family. (529 aa)
VIPVasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (167 aa)
SAL1Salivary lipocalin; Binds pheromones, the pheromones are released from the saliva of males and affect the sexual behavior of females. (191 aa)
PTGESMicrosomal prostaglandin E synthase-1. (153 aa)
GKUncharacterized protein; Belongs to the FGGY kinase family. (590 aa)
PLPP1Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these [...] (290 aa)
FASNUncharacterized protein. (1430 aa)
CYP4F8Cytochrome P450 family 4 subfamily F member 8; Belongs to the cytochrome P450 family. (678 aa)
PSPHPhosphoserine phosphatase isoform X1. (225 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (646 aa)
MGLLMonoglyceride lipase. (456 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
ELOVL6Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
HACD2Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (254 aa)
GPX1Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (205 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
DGAT2Uncharacterized protein. (339 aa)
DGKBDiacylglycerol kinase. (802 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (503 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
PLA2G4APhospholipase A2. (758 aa)
GGT5Gamma-glutamyltransferase 5. (639 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (649 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (547 aa)
SDSSerine dehydratase. (402 aa)
PLPP2Phospholipid phosphatase 2. (368 aa)
CBR4Carbonyl reductase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa)
PLPP3acidPPc domain-containing protein. (369 aa)
LPIN1Lipin 1. (957 aa)
LOC110256000Amine oxidase; Belongs to the copper/topaquinone oxidase family. (751 aa)
SCDAcyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid ox [...] (425 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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