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NDUFS3 NDUFS3 PFKM PFKM PRKAA1 PRKAA1 MYL4 MYL4 LOC100521680 LOC100521680 PRKAG2 PRKAG2 ATP5PO ATP5PO PRKAB1 PRKAB1 PRKAB2 PRKAB2 PSMB5 PSMB5 PSMA3 PSMA3 MYH11 MYH11 PDK4 PDK4 PSMB6 PSMB6 MYH7 MYH7 HIST1H3E HIST1H3E PRKAA2 PRKAA2 PSMB1 PSMB1 PSMA7 PSMA7 PSMA2 PSMA2 PSMB2 PSMB2 PSMB4 PSMB4 PFKL PFKL A0A286ZTM7_PIG A0A286ZTM7_PIG PSMB3 PSMB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NDUFS3NADH dehydrogenase ubiquinone iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (264 aa)
PFKMATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (810 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
MYL4Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. (197 aa)
LOC100521680Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (619 aa)
ATP5POATP synthase subunit O, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (213 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] (271 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PSMB5Uncharacterized protein. (84 aa)
PSMA3Proteasome subunit alpha type. (275 aa)
MYH11Myosin-11; Muscle contraction. (1761 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
PSMB6Uncharacterized protein. (334 aa)
MYH7Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2052 aa)
HIST1H3EHistone H3; Belongs to the histone H3 family. (136 aa)
PRKAA25'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMA7Proteasome subunit alpha type. (267 aa)
PSMA2Proteasome endopeptidase complex. (243 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMB4Proteasome subunit beta type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (264 aa)
PFKL6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (782 aa)
A0A286ZTM7_PIGHistone H3; Belongs to the histone H3 family. (136 aa)
PSMB3Proteasome subunit beta. (205 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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