STRINGSTRING
STAT1 STAT1 STAT2 STAT2 HDAC9 HDAC9 HDAC4 HDAC4 HDAC7 HDAC7 IFNAR1 IFNAR1 HIST1H3E HIST1H3E PRPS2 PRPS2 CHUK CHUK MAVS MAVS IFNB1 IFNB1 NFKBIA NFKBIA RNF5 RNF5 TRIM25 TRIM25 LOC100521680 LOC100521680 TLR3 TLR3 TLR8 TLR8 PARP1 PARP1 CCL5 CCL5 IFNGR1 IFNGR1 IRF3 IRF3 IFIT2 IFIT2 HDAC5 HDAC5 SAV1 SAV1 JAK1 JAK1 NBR1 NBR1 LATS1 LATS1 ISG15 ISG15 TYK2 TYK2 A0A286ZTM7_PIG A0A286ZTM7_PIG
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
STAT1Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa)
STAT2Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] (900 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1137 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1160 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (980 aa)
IFNAR1Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). (617 aa)
HIST1H3EHistone H3; Belongs to the histone H3 family. (136 aa)
PRPS2TIR domain-containing protein. (1337 aa)
CHUKProtein kinase domain-containing protein. (580 aa)
MAVSMitochondrial antiviral signaling protein. (532 aa)
IFNB1Interferon-beta-1. (186 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
RNF5E3 ubiquitin-protein ligase RNF5. (180 aa)
TRIM25Tripartite motif containing 25. (633 aa)
LOC100521680Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (903 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1117 aa)
PARP1Poly [ADP-ribose] polymerase. (1017 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
IFNGR1Interferon gamma receptor 1. (470 aa)
IRF3Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...] (452 aa)
IFIT2Interferon induced protein with tetratricopeptide repeats 2. (473 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1131 aa)
SAV1Salvador family WW domain containing protein 1. (433 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
NBR1Next to BRCA1 gene 1 protein isoform X1. (960 aa)
LATS1Large tumor suppressor kinase 1. (1146 aa)
ISG15Ubiquitin-like modifier. (167 aa)
TYK2Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1226 aa)
A0A286ZTM7_PIGHistone H3; Belongs to the histone H3 family. (136 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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