node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HMGCR | PPARG | ENSSSCP00000053515 | ENSSSCP00000012339 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.599 |
MYC | PPARG | ENSSSCP00000074218 | ENSSSCP00000012339 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.421 |
PNLIP | PNLIPRP1 | ENSSSCP00000011355 | ENSSSCP00000011357 | Pancreatic triacylglycerol lipase. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.909 |
PNLIP | PNLIPRP2 | ENSSSCP00000011355 | ENSSSCP00000050863 | Pancreatic triacylglycerol lipase. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.902 |
PNLIP | PNLIPRP3 | ENSSSCP00000011355 | ENSSSCP00000011354 | Pancreatic triacylglycerol lipase. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.903 |
PNLIPRP1 | PNLIP | ENSSSCP00000011357 | ENSSSCP00000011355 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Pancreatic triacylglycerol lipase. | 0.909 |
PNLIPRP1 | PNLIPRP2 | ENSSSCP00000011357 | ENSSSCP00000050863 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.903 |
PNLIPRP1 | PNLIPRP3 | ENSSSCP00000011357 | ENSSSCP00000011354 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.903 |
PNLIPRP2 | PNLIP | ENSSSCP00000050863 | ENSSSCP00000011355 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Pancreatic triacylglycerol lipase. | 0.902 |
PNLIPRP2 | PNLIPRP1 | ENSSSCP00000050863 | ENSSSCP00000011357 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.903 |
PNLIPRP2 | PNLIPRP3 | ENSSSCP00000050863 | ENSSSCP00000011354 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.903 |
PNLIPRP3 | PNLIP | ENSSSCP00000011354 | ENSSSCP00000011355 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Pancreatic triacylglycerol lipase. | 0.903 |
PNLIPRP3 | PNLIPRP1 | ENSSSCP00000011354 | ENSSSCP00000011357 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.903 |
PNLIPRP3 | PNLIPRP2 | ENSSSCP00000011354 | ENSSSCP00000050863 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.903 |
PPARG | HMGCR | ENSSSCP00000012339 | ENSSSCP00000053515 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. | 0.599 |
PPARG | MYC | ENSSSCP00000012339 | ENSSSCP00000074218 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.421 |
PPARG | SLC2A4 | ENSSSCP00000012339 | ENSSSCP00000018998 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. | 0.805 |
SLC2A4 | PPARG | ENSSSCP00000018998 | ENSSSCP00000012339 | Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.805 |