node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IFNB1 | JAK1 | ENSSSCP00000005550 | ENSSSCP00000032415 | Interferon-beta-1. | Tyrosine-protein kinase. | 0.894 |
IFNB1 | STAT1 | ENSSSCP00000005550 | ENSSSCP00000033087 | Interferon-beta-1. | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] | 0.839 |
IFNB1 | STAT2 | ENSSSCP00000005550 | ENSSSCP00000069374 | Interferon-beta-1. | Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] | 0.869 |
IFNB1 | STAT4 | ENSSSCP00000005550 | ENSSSCP00000020218 | Interferon-beta-1. | Signal transducer and activator of transcription. | 0.633 |
IFNB1 | STAT6 | ENSSSCP00000005550 | ENSSSCP00000019659 | Interferon-beta-1. | Signal transducer and activator of transcription. | 0.597 |
IFNB1 | TYK2 | ENSSSCP00000005550 | ENSSSCP00000035640 | Interferon-beta-1. | Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.866 |
JAK1 | IFNB1 | ENSSSCP00000032415 | ENSSSCP00000005550 | Tyrosine-protein kinase. | Interferon-beta-1. | 0.894 |
JAK1 | STAT1 | ENSSSCP00000032415 | ENSSSCP00000033087 | Tyrosine-protein kinase. | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] | 0.998 |
JAK1 | STAT2 | ENSSSCP00000032415 | ENSSSCP00000069374 | Tyrosine-protein kinase. | Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] | 0.993 |
JAK1 | STAT4 | ENSSSCP00000032415 | ENSSSCP00000020218 | Tyrosine-protein kinase. | Signal transducer and activator of transcription. | 0.986 |
JAK1 | STAT6 | ENSSSCP00000032415 | ENSSSCP00000019659 | Tyrosine-protein kinase. | Signal transducer and activator of transcription. | 0.985 |
JAK1 | TYK2 | ENSSSCP00000032415 | ENSSSCP00000035640 | Tyrosine-protein kinase. | Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.954 |
STAT1 | IFNB1 | ENSSSCP00000033087 | ENSSSCP00000005550 | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] | Interferon-beta-1. | 0.839 |
STAT1 | JAK1 | ENSSSCP00000033087 | ENSSSCP00000032415 | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] | Tyrosine-protein kinase. | 0.998 |
STAT1 | STAT2 | ENSSSCP00000033087 | ENSSSCP00000069374 | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] | Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] | 0.999 |
STAT1 | STAT4 | ENSSSCP00000033087 | ENSSSCP00000020218 | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] | Signal transducer and activator of transcription. | 0.833 |
STAT1 | STAT6 | ENSSSCP00000033087 | ENSSSCP00000019659 | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] | Signal transducer and activator of transcription. | 0.816 |
STAT1 | TYK2 | ENSSSCP00000033087 | ENSSSCP00000035640 | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] | Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.945 |
STAT2 | IFNB1 | ENSSSCP00000069374 | ENSSSCP00000005550 | Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] | Interferon-beta-1. | 0.869 |
STAT2 | JAK1 | ENSSSCP00000069374 | ENSSSCP00000032415 | Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] | Tyrosine-protein kinase. | 0.993 |