7 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IFIT1	Interferon-stimulated protein 60. (509 aa)
	HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5. (968 aa)
	IRF3	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...] (452 aa)
	ALKBH5	AlkB homolog 5, RNA demethylase. (394 aa)
	ISG15	Ubiquitin-like modifier. (167 aa)
	TBK1	TANK binding kinase TBK1. (729 aa)
	YTHDC2	YTH domain containing 2. (1430 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALKBH5	YTHDC2	ENSSSCP00000038766	ENSSSCP00000048904	AlkB homolog 5, RNA demethylase.	YTH domain containing 2.	0.858
HERC5	IFIT1	ENSSSCP00000020915	ENSSSCP00000011141	HECT and RLD domain containing E3 ubiquitin protein ligase 5.	Interferon-stimulated protein 60.	0.713
HERC5	IRF3	ENSSSCP00000020915	ENSSSCP00000028920	HECT and RLD domain containing E3 ubiquitin protein ligase 5.	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...]	0.722
HERC5	ISG15	ENSSSCP00000020915	ENSSSCP00000041015	HECT and RLD domain containing E3 ubiquitin protein ligase 5.	Ubiquitin-like modifier.	0.970
IFIT1	HERC5	ENSSSCP00000011141	ENSSSCP00000020915	Interferon-stimulated protein 60.	HECT and RLD domain containing E3 ubiquitin protein ligase 5.	0.713
IFIT1	IRF3	ENSSSCP00000011141	ENSSSCP00000028920	Interferon-stimulated protein 60.	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...]	0.657
IFIT1	ISG15	ENSSSCP00000011141	ENSSSCP00000041015	Interferon-stimulated protein 60.	Ubiquitin-like modifier.	0.930
IFIT1	TBK1	ENSSSCP00000011141	ENSSSCP00000046241	Interferon-stimulated protein 60.	TANK binding kinase TBK1.	0.640
IRF3	HERC5	ENSSSCP00000028920	ENSSSCP00000020915	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...]	HECT and RLD domain containing E3 ubiquitin protein ligase 5.	0.722
IRF3	IFIT1	ENSSSCP00000028920	ENSSSCP00000011141	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...]	Interferon-stimulated protein 60.	0.657
IRF3	ISG15	ENSSSCP00000028920	ENSSSCP00000041015	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...]	Ubiquitin-like modifier.	0.990
IRF3	TBK1	ENSSSCP00000028920	ENSSSCP00000046241	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...]	TANK binding kinase TBK1.	0.999
ISG15	HERC5	ENSSSCP00000041015	ENSSSCP00000020915	Ubiquitin-like modifier.	HECT and RLD domain containing E3 ubiquitin protein ligase 5.	0.970
ISG15	IFIT1	ENSSSCP00000041015	ENSSSCP00000011141	Ubiquitin-like modifier.	Interferon-stimulated protein 60.	0.930
ISG15	IRF3	ENSSSCP00000041015	ENSSSCP00000028920	Ubiquitin-like modifier.	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...]	0.990
ISG15	TBK1	ENSSSCP00000041015	ENSSSCP00000046241	Ubiquitin-like modifier.	TANK binding kinase TBK1.	0.729
TBK1	IFIT1	ENSSSCP00000046241	ENSSSCP00000011141	TANK binding kinase TBK1.	Interferon-stimulated protein 60.	0.640
TBK1	IRF3	ENSSSCP00000046241	ENSSSCP00000028920	TANK binding kinase TBK1.	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...]	0.999
TBK1	ISG15	ENSSSCP00000046241	ENSSSCP00000041015	TANK binding kinase TBK1.	Ubiquitin-like modifier.	0.729
YTHDC2	ALKBH5	ENSSSCP00000048904	ENSSSCP00000038766	YTH domain containing 2.	AlkB homolog 5, RNA demethylase.	0.858