Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CASP1 | CASP6 | ENSSSCP00000064928 | ENSSSCP00000068855 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | Caspase 6; Belongs to the peptidase C14A family. | 0.527 |
| CASP1 | CASP8 | ENSSSCP00000064928 | ENSSSCP00000026484 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | Caspase-8 isoform X2; Belongs to the peptidase C14A family. | 0.985 |
| CASP1 | F1SV37_PIG | ENSSSCP00000064928 | ENSSSCP00000015921 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.571 |
| CASP1 | LOC100522887 | ENSSSCP00000064928 | ENSSSCP00000015922 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.813 |
| CASP10 | CASP3 | ENSSSCP00000026681 | ENSSSCP00000049424 | Caspase 10; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). | 0.958 |
| CASP10 | CASP6 | ENSSSCP00000026681 | ENSSSCP00000068855 | Caspase 10; Belongs to the peptidase C14A family. | Caspase 6; Belongs to the peptidase C14A family. | 0.640 |
| CASP10 | CASP7 | ENSSSCP00000026681 | ENSSSCP00000043126 | Caspase 10; Belongs to the peptidase C14A family. | Caspase 7; Belongs to the peptidase C14A family. | 0.939 |
| CASP10 | CASP8 | ENSSSCP00000026681 | ENSSSCP00000026484 | Caspase 10; Belongs to the peptidase C14A family. | Caspase-8 isoform X2; Belongs to the peptidase C14A family. | 0.979 |
| CASP10 | CASP9 | ENSSSCP00000026681 | ENSSSCP00000003758 | Caspase 10; Belongs to the peptidase C14A family. | Caspase 9; Belongs to the peptidase C14A family. | 0.651 |
| CASP10 | CFLAR | ENSSSCP00000026681 | ENSSSCP00000037053 | Caspase 10; Belongs to the peptidase C14A family. | CASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. | 0.976 |
| CASP10 | F1SV37_PIG | ENSSSCP00000026681 | ENSSSCP00000015921 | Caspase 10; Belongs to the peptidase C14A family. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.477 |
| CASP14 | CASP9 | ENSSSCP00000014708 | ENSSSCP00000003758 | Caspase 14, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Caspase 9; Belongs to the peptidase C14A family. | 0.403 |
| CASP3 | CASP10 | ENSSSCP00000049424 | ENSSSCP00000026681 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). | Caspase 10; Belongs to the peptidase C14A family. | 0.958 |
| CASP3 | CASP6 | ENSSSCP00000049424 | ENSSSCP00000068855 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). | Caspase 6; Belongs to the peptidase C14A family. | 0.631 |
| CASP3 | CASP7 | ENSSSCP00000049424 | ENSSSCP00000043126 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). | Caspase 7; Belongs to the peptidase C14A family. | 0.916 |
| CASP3 | CASP8 | ENSSSCP00000049424 | ENSSSCP00000026484 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). | Caspase-8 isoform X2; Belongs to the peptidase C14A family. | 0.986 |
| CASP3 | CASP9 | ENSSSCP00000049424 | ENSSSCP00000003758 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). | Caspase 9; Belongs to the peptidase C14A family. | 0.979 |
| CASP3 | CFLAR | ENSSSCP00000049424 | ENSSSCP00000037053 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). | CASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. | 0.464 |
| CASP6 | CASP1 | ENSSSCP00000068855 | ENSSSCP00000064928 | Caspase 6; Belongs to the peptidase C14A family. | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] | 0.527 |
| CASP6 | CASP10 | ENSSSCP00000068855 | ENSSSCP00000026681 | Caspase 6; Belongs to the peptidase C14A family. | Caspase 10; Belongs to the peptidase C14A family. | 0.640 |
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