(20 nodes) Rho (Ras homology) subfamily of Ras-like small GTPases network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RHOV	Uncharacterized protein. (236 aa)
	RHOC	Ras homolog family member C. (202 aa)
	RHOF	Ras homolog family member F, filopodia associated. (249 aa)
	RHOU	Ras homolog family member U. (258 aa)
	RHOD	Ras homolog family member D. (203 aa)
	F1RSX1_PIG	Uncharacterized protein. (200 aa)
	RND2	Rho family GTPase 2. (231 aa)
	RHOJ	Uncharacterized protein. (213 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
	RHOH	Rho-related GTP-binding protein RhoH. (191 aa)
	RHOQ	Rho-related GTP-binding protein RhoQ. (205 aa)
	RHOBTB1	Rho-related BTB domain-containing protein 1 isoform 1. (698 aa)
	RHOA	Transforming protein RhoA isoform 1. (193 aa)
	RAC3	Rac family small GTPase 3. (192 aa)
	RND3	Rho-related GTP-binding protein RhoE; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. (244 aa)
	RHOG	Uncharacterized protein. (394 aa)
	RND1	Rho family GTPase 1. (244 aa)
	RAC1	Rac family small GTPase 1. (186 aa)
	RHOB	Rho-related GTP-binding protein RhoB. (196 aa)
	RAC2	Rac family small GTPase 2. (217 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	RAC1	ENSSSCP00000029815	ENSSSCP00000062132	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Rac family small GTPase 1.	0.783
CDC42	RAC2	ENSSSCP00000029815	ENSSSCP00000070230	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Rac family small GTPase 2.	0.931
CDC42	RAC3	ENSSSCP00000029815	ENSSSCP00000047362	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Rac family small GTPase 3.	0.929
CDC42	RHOA	ENSSSCP00000029815	ENSSSCP00000045785	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Transforming protein RhoA isoform 1.	0.948
CDC42	RHOB	ENSSSCP00000029815	ENSSSCP00000069510	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Rho-related GTP-binding protein RhoB.	0.432
CDC42	RHOC	ENSSSCP00000029815	ENSSSCP00000007228	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Ras homolog family member C.	0.505
CDC42	RHOG	ENSSSCP00000029815	ENSSSCP00000051183	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Uncharacterized protein.	0.540
CDC42	RHOQ	ENSSSCP00000029815	ENSSSCP00000038926	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Rho-related GTP-binding protein RhoQ.	0.524
CDC42	RHOU	ENSSSCP00000029815	ENSSSCP00000019612	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Ras homolog family member U.	0.531
CDC42	RHOV	ENSSSCP00000029815	ENSSSCP00000005130	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Uncharacterized protein.	0.534
F1RSX1_PIG	RHOG	ENSSSCP00000026359	ENSSSCP00000051183	Uncharacterized protein.	Uncharacterized protein.	0.901
RAC1	CDC42	ENSSSCP00000062132	ENSSSCP00000029815	Rac family small GTPase 1.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.783
RAC1	RAC2	ENSSSCP00000062132	ENSSSCP00000070230	Rac family small GTPase 1.	Rac family small GTPase 2.	0.505
RAC1	RHOA	ENSSSCP00000062132	ENSSSCP00000045785	Rac family small GTPase 1.	Transforming protein RhoA isoform 1.	0.569
RAC1	RHOB	ENSSSCP00000062132	ENSSSCP00000069510	Rac family small GTPase 1.	Rho-related GTP-binding protein RhoB.	0.636
RAC1	RHOC	ENSSSCP00000062132	ENSSSCP00000007228	Rac family small GTPase 1.	Ras homolog family member C.	0.636
RAC1	RHOG	ENSSSCP00000062132	ENSSSCP00000051183	Rac family small GTPase 1.	Uncharacterized protein.	0.513
RAC1	RND1	ENSSSCP00000062132	ENSSSCP00000059270	Rac family small GTPase 1.	Rho family GTPase 1.	0.651
RAC2	CDC42	ENSSSCP00000070230	ENSSSCP00000029815	Rac family small GTPase 2.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.931
RAC2	RAC1	ENSSSCP00000070230	ENSSSCP00000062132	Rac family small GTPase 2.	Rac family small GTPase 1.	0.505