36 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCN5	WNT1-inducible-signaling pathway protein 2 isoform 1. (244 aa)
	CHRDL2	Chordin like 2. (452 aa)
	BMPER	BMP binding endothelial regulator. (699 aa)
	MUC2	Uncharacterized protein. (3289 aa)
	FRAS1	Fraser extracellular matrix complex subunit 1. (4013 aa)
	ZAN	Zonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling. (2676 aa)
	CCN1	Cellular communication network factor 1. (382 aa)
	COL1A1	Collagen type I alpha 1 chain. (1477 aa)
	RECK	Reversion-inducing cysteine-rich protein with Kazal motifs isoform 1. (971 aa)
	TECTA	Tectorin alpha. (2469 aa)
	VWC2L	Von Willebrand factor C domain-containing protein 2-like isoform 1. (222 aa)
	THBS2	Thrombospondin 2. (1223 aa)
	VWC2	Von Willebrand factor C domain containing 2. (325 aa)
	CCN6	WNT1-inducible-signaling pathway protein 3 isoform 3. (354 aa)
	NELL1	Protein kinase C-binding protein NELL1 isoform 1. (810 aa)
	COL5A2	Collagen alpha-2(V) chain preproprotein. (1499 aa)
	CHRD	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (1028 aa)
	NELL2	Neural EGFL like 2. (826 aa)
	DGCR2	Uncharacterized protein. (1093 aa)
	CCN4	WNT1-inducible-signaling pathway protein 1 isoform X1. (371 aa)
	MUC5AC	Uncharacterized protein. (3330 aa)
	FCGBP	Uncharacterized protein. (2505 aa)
	CCN2	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). (354 aa)
	COL2A1	Collagen type II alpha 1 chain. (1486 aa)
	COL3A1	Collagen alpha-1(III) chain preproprotein. (1471 aa)
	CHRDL1	Chordin like 1. (526 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1371 aa)
	ECM2	Extracellular matrix protein 2. (696 aa)
	PXDN	Peroxidasin. (1529 aa)
	KCP	Kielin cysteine rich BMP regulator. (1783 aa)
	VWCE	Von Willebrand factor C and EGF domains. (941 aa)
	CRIM1	Cysteine rich transmembrane BMP regulator 1. (1031 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa)
	CCN3	Cellular communication network factor 3. (398 aa)
	THBS1	Uncharacterized protein. (1170 aa)
	VWF	Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (2940 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMPER	CHRD	ENSSSCP00000069280	ENSSSCP00000051552	BMP binding endothelial regulator.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.774
BMPER	VWC2	ENSSSCP00000069280	ENSSSCP00000057862	BMP binding endothelial regulator.	Von Willebrand factor C domain containing 2.	0.584
CCN1	THBS1	ENSSSCP00000066979	ENSSSCP00000005158	Cellular communication network factor 1.	Uncharacterized protein.	0.617
CCN1	VWF	ENSSSCP00000066979	ENSSSCP00000000759	Cellular communication network factor 1.	Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).	0.504
CCN2	COL1A1	ENSSSCP00000037172	ENSSSCP00000066291	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).	Collagen type I alpha 1 chain.	0.825
CCN2	COL3A1	ENSSSCP00000037172	ENSSSCP00000033771	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).	Collagen alpha-1(III) chain preproprotein.	0.662
CCN2	COL5A2	ENSSSCP00000037172	ENSSSCP00000055229	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).	Collagen alpha-2(V) chain preproprotein.	0.400
CCN2	PXDN	ENSSSCP00000037172	ENSSSCP00000022033	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).	Peroxidasin.	0.617
CCN2	THBS1	ENSSSCP00000037172	ENSSSCP00000005158	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).	Uncharacterized protein.	0.714
CCN2	THBS2	ENSSSCP00000037172	ENSSSCP00000061166	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).	Thrombospondin 2.	0.422
CCN2	VWF	ENSSSCP00000037172	ENSSSCP00000000759	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).	Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).	0.532
CCN6	VWF	ENSSSCP00000056836	ENSSSCP00000000759	WNT1-inducible-signaling pathway protein 3 isoform 3.	Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).	0.534
CHRD	BMPER	ENSSSCP00000051552	ENSSSCP00000069280	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	BMP binding endothelial regulator.	0.774
CHRD	CHRDL2	ENSSSCP00000051552	ENSSSCP00000070661	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Chordin like 2.	0.501
CHRD	VWCE	ENSSSCP00000051552	ENSSSCP00000013927	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Von Willebrand factor C and EGF domains.	0.427
CHRD	VWF	ENSSSCP00000051552	ENSSSCP00000000759	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity).	0.539
CHRDL2	CHRD	ENSSSCP00000070661	ENSSSCP00000051552	Chordin like 2.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.501
CHRDL2	VWCE	ENSSSCP00000070661	ENSSSCP00000013927	Chordin like 2.	Von Willebrand factor C and EGF domains.	0.440
COL1A1	CCN2	ENSSSCP00000066291	ENSSSCP00000037172	Collagen type I alpha 1 chain.	CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).	0.825
COL1A1	COL2A1	ENSSSCP00000066291	ENSSSCP00000036099	Collagen type I alpha 1 chain.	Collagen type II alpha 1 chain.	0.751