STRINGSTRING
USP28 USP28 PSMD4 PSMD4 USP37 USP37 EPN3 EPN3 ANKRD13B ANKRD13B UIMC1 UIMC1 USP25 USP25 ANKIB1 ANKIB1 EPN1 EPN1 ZFAND2B ZFAND2B STAM2 STAM2 EPS15L1 EPS15L1 EPN2 EPN2 EPS15 EPS15 HGS HGS STAM STAM DNAJB2 DNAJB2 ANKRD13A ANKRD13A ANKRD13D ANKRD13D ATXN3 ATXN3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
USP28Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1130 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
USP37Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] (980 aa)
EPN3Epsin-3. (612 aa)
ANKRD13BAnkyrin repeat domain 13B. (840 aa)
UIMC1BRCA1-A complex subunit RAP80; Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. M [...] (622 aa)
USP25Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1152 aa)
ANKIB1RBR-type E3 ubiquitin transferase. (1092 aa)
EPN1Epsin 1. (576 aa)
ZFAND2BZinc finger AN1-type containing 2B. (304 aa)
STAM2Signal transducing adaptor molecule 2. (517 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (944 aa)
EPN2Epsin 2. (704 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (979 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (908 aa)
STAMSignal transducing adaptor molecule. (521 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (334 aa)
ANKRD13AAnkyrin repeat domain 13A. (600 aa)
ANKRD13DAnkyrin repeat domain 13D. (626 aa)
ATXN3Josephin domain-containing protein. (359 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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