STRINGSTRING
SPAST SPAST RPS6KL1 RPS6KL1 MITD1 MITD1 VPS4A VPS4A CAPN7 CAPN7 ULK3 ULK3 RPS6KC1 RPS6KC1 VPS4B VPS4B SPART SPART SNX15 SNX15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (615 aa)
RPS6KL1Ribosomal protein S6 kinase like 1. (593 aa)
MITD1Microtubule interacting and trafficking domain containing 1. (249 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (518 aa)
CAPN7Calpain-7; Calcium-regulated non-lysosomal thiol-protease. Belongs to the peptidase C2 family. (769 aa)
ULK3Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (472 aa)
RPS6KC1Ribosomal protein S6 kinase delta-1 isoform X3. (1051 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa)
SPARTSpartin. (666 aa)
SNX15Sorting nexin 15. (369 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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