STRINGSTRING
RPA3 RPA3 POLE3 POLE3 RFC4 RFC4 CUL4B CUL4B DDB1 DDB1 KXD1 KXD1 DTL DTL POLD3 POLD3 RAD18 RAD18 RPA1 RPA1 RFC1 RFC1 POLD2 POLD2 RFC5 RFC5 USP1 USP1 PCNA PCNA UBE2B UBE2B RPS27A RPS27A RBX1 RBX1 POLE POLE POLD1 POLD1 RFC2 RFC2 POLD4 POLD4 UBC UBC RFC3 RFC3 CUL4A CUL4A WDR48 WDR48 POLE4 POLE4 RPA2 RPA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA3Replication protein A3. (121 aa)
POLE3Uncharacterized protein. (171 aa)
RFC4Replication factor C subunit 4. (364 aa)
CUL4BCullin 4B; Belongs to the cullin family. (1056 aa)
DDB1Damage specific DNA binding protein 1. (1139 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (729 aa)
POLD3Uncharacterized protein. (463 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (547 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
RFC1Replication factor C subunit 1. (1141 aa)
POLD2DNA polymerase delta 2, accessory subunit. (471 aa)
RFC5Replication factor C subunit 5. (343 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (784 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa)
UBE2BUbiquitin-conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
POLD1DNA polymerase. (1152 aa)
RFC2Replication factor C subunit 2 isoform 1. (352 aa)
POLD4Uncharacterized protein. (134 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
RFC3Replication factor C subunit 3 isoform 1. (356 aa)
CUL4ACullin 4A; Belongs to the cullin family. (712 aa)
WDR48WD repeat domain 48. (740 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (138 aa)
RPA2RPA_C domain-containing protein. (270 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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