STRINGSTRING
VEGFC VEGFC A2M A2M ISLR ISLR VTI1B VTI1B THBS1 THBS1 TOR4A TOR4A TAGLN2 TAGLN2 PDGFA PDGFA ANXA5 ANXA5 MMRN1 MMRN1 VCL VCL NHLRC2 NHLRC2 LOC100524517 LOC100524517 SCCPDH SCCPDH TEX264 TEX264 HRG HRG APP APP VEGFD VEGFD SYTL4 SYTL4 SERPING1 SERPING1 CFD CFD PCYOX1L PCYOX1L ENDOD1 ENDOD1 HGF HGF FN1 FN1 GTPBP2 GTPBP2 LEFTY2 LEFTY2 ECM1 ECM1 SELENOP SELENOP FGG FGG SRGN SRGN ACTN1 ACTN1 SERPINE1 SERPINE1 SOD1 SOD1 CD109 CD109 TMSB4X TMSB4X APOH APOH CD63 CD63 TGFB1 TGFB1 TGFB3 TGFB3 LHFPL2 LHFPL2 SERPINA4 SERPINA4 WDR1 WDR1 RAB27B RAB27B CYB5R1 CYB5R1 TIMP3 TIMP3 CTSW CTSW APLP2 APLP2 PROS1 PROS1 ACTN4 ACTN4 ACTG1 ACTG1 LY6G6D LY6G6D TLN1 TLN1 PDGFB PDGFB CLEC3B CLEC3B SCG3 SCG3 LOC100621494 LOC100621494 PECAM1 PECAM1 HABP4 HABP4 FLNA FLNA FAM3C FAM3C GAS6 GAS6 FAM49B FAM49B RARRES2 RARRES2 CLU CLU LAMP2 LAMP2 SERPINF2 SERPINF2 ABCC4 ABCC4 ALDOA ALDOA SERPINA3-2 SERPINA3-2 IGF2 IGF2 ITIH3 ITIH3 CDC37L1 CDC37L1 FERMT3 FERMT3 APOOL APOOL CHID1 CHID1 ACTN2 ACTN2 PHACTR2 PHACTR2 PCDH7 PCDH7 PLEK PLEK KNG1 KNG1 QSOX1 QSOX1 MANF MANF TMX3 TMX3 ORM1 ORM1 OLA1 OLA1 BRPF3 BRPF3 F13A1 F13A1 TUBA4A TUBA4A PPBP PPBP SPARC SPARC SELP SELP LGALS3BP LGALS3BP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
A2MAlpha-2-macroglobulin. (1504 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (436 aa)
VTI1Bt-SNARE coiled-coil homology domain-containing protein. (232 aa)
THBS1Uncharacterized protein. (1170 aa)
TOR4ATorsin family 4 member A. (415 aa)
TAGLN2Transgelin; Belongs to the calponin family. (213 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (286 aa)
ANXA5Annexin. (321 aa)
MMRN1Multimerin 1. (1220 aa)
VCLVinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa)
NHLRC2NHL repeat-containing protein 2. (725 aa)
LOC100524517Left-right determination factor. (373 aa)
SCCPDHSacchrp_dh_NADP domain-containing protein. (429 aa)
TEX264Testis expressed 264, ER-phagy receptor. (284 aa)
HRGUncharacterized protein. (561 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa)
VEGFDVascular endothelial growth factor D preproprotein; Belongs to the PDGF/VEGF growth factor family. (354 aa)
SYTL4Synaptotagmin like 4. (721 aa)
SERPING1Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. (491 aa)
CFDComplement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity). (259 aa)
PCYOX1LPrenylcysteine oxidase 1 like. (457 aa)
ENDOD1Endonuclease domain containing 1. (500 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
FN1Fibronectin 1. (2462 aa)
GTPBP2GTP binding protein 2. (694 aa)
LEFTY2Left-right determination factor. (366 aa)
ECM1Extracellular matrix protein 1. (559 aa)
SELENOPUncharacterized protein. (390 aa)
FGGFibrinogen gamma chain. (454 aa)
SRGNSerglycin. (152 aa)
ACTN1Uncharacterized protein. (888 aa)
SERPINE1Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. I [...] (401 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (155 aa)
CD109CD109 antigen isoform 1 preproprotein. (1449 aa)
TMSB4XHematopoietic system regulatory peptide; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization; Belongs to the thymosin beta family. (44 aa)
APOHBeta-2-glycoprotein 1. (345 aa)
CD63Tetraspanin. (237 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (456 aa)
LHFPL2LHFPL tetraspan subfamily member 2 protein isoform X1. (228 aa)
SERPINA4Serpin family A member 4; Belongs to the serpin family. (371 aa)
WDR1WD repeat-containing protein 1 isoform 1. (606 aa)
RAB27BRAB27B, member RAS oncogene family. (247 aa)
CYB5R1Cytochrome b5 reductase 1. (487 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (368 aa)
APLP2Amyloid beta precursor like protein 2. (770 aa)
PROS1Protein S. (702 aa)
ACTN4Actinin alpha 4. (1160 aa)
ACTG1Actin gamma 1. (381 aa)
LY6G6DIg-like domain-containing protein. (445 aa)
TLN1Talin 1. (2558 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
CLEC3BC-type lectin domain family 3 member B. (202 aa)
SCG3Secretogranin III. (549 aa)
LOC100621494SERPIN domain-containing protein; Belongs to the serpin family. (407 aa)
PECAM1Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa)
HABP4Intracellular hyaluronan-binding protein 4. (418 aa)
FLNAFilamin A. (2897 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
GAS6Uncharacterized protein. (682 aa)
FAM49BUncharacterized protein. (468 aa)
RARRES2Retinoic acid receptor responder 2. (177 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (472 aa)
LAMP2Lysosome-associated membrane glycoprotein 2 isoform A. (411 aa)
SERPINF2Alpha-2-antiplasmin isoform X2; Belongs to the serpin family. (563 aa)
ABCC4Multidrug resistance-associated protein 4 isoform X1. (1325 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (532 aa)
SERPINA3-2SERPIN domain-containing protein; Belongs to the serpin family. (473 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (583 aa)
ITIH3Inter-alpha-trypsin inhibitor heavy chain 3. (907 aa)
CDC37L1Cell division cycle 37 like 1. (339 aa)
FERMT3Fermitin family member 3. (667 aa)
APOOLMICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (268 aa)
CHID1Chitinase domain containing 1. (511 aa)
ACTN2Uncharacterized protein. (933 aa)
PHACTR2Phosphatase and actin regulator. (759 aa)
PCDH7Uncharacterized protein. (1246 aa)
PLEKPleckstrin. (408 aa)
KNG1Kininogen 1. (630 aa)
QSOX1Sulfhydryl oxidase. (742 aa)
MANFUncharacterized protein. (189 aa)
TMX3Thioredoxin related transmembrane protein 3. (454 aa)
ORM1Lipocln_cytosolic_FA-bd_dom domain-containing protein. (212 aa)
OLA1Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (413 aa)
BRPF3Bromodomain and PHD finger containing 3. (1150 aa)
F13A1Coagulation factor XIII A chain. (774 aa)
TUBA4ATubulin alpha 4a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (618 aa)
PPBPPlatelet basic protein; Chemoattractant factor for neutrophils. (159 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (331 aa)
SELPUncharacterized protein. (671 aa)
LGALS3BPGalectin 3 binding protein. (551 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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