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ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1342 aa) | ||||
FYN | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa) | ||||
PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) | ||||
SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa) | ||||
MEMO1 | Mediator of cell motility 1. (297 aa) | ||||
KXD1 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa) | ||||
PTPN18 | Tyrosine-protein phosphatase non-receptor type 18 isoform X1. (454 aa) | ||||
ERBB4 | Receptor protein-tyrosine kinase. (1201 aa) | ||||
GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) | ||||
PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa) | ||||
GRB7 | Growth factor receptor bound protein 7. (569 aa) | ||||
ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) | ||||
MATK | Tyrosine-protein kinase. (485 aa) | ||||
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) | ||||
PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa) | ||||
STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) | ||||
HBEGF | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa) | ||||
YES1 | Tyrosine-protein kinase. (553 aa) | ||||
UBC | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa) | ||||
EREG | Epiregulin. (168 aa) | ||||
NRG2 | Neuregulin 2. (858 aa) | ||||
EGFR | Receptor protein-tyrosine kinase. (1205 aa) | ||||
KRAS | KRAS proto-oncogene, GTPase. (189 aa) | ||||
CUL5 | Cullin-5; Belongs to the cullin family. (780 aa) | ||||
PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (766 aa) | ||||
SHC1 | SHC adaptor protein 1. (583 aa) | ||||
GAB1 | GRB2 associated binding protein 1. (723 aa) | ||||
SRC | Tyrosine-protein kinase. (559 aa) | ||||
NRG3 | Neuregulin 3. (718 aa) | ||||
USP8 | Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1115 aa) | ||||
PTK6 | Tyrosine-protein kinase. (449 aa) | ||||
RNF41 | E3 ubiquitin-protein ligase NRDP1 isoform 1. (317 aa) | ||||
BTC | EGF-like domain-containing protein. (342 aa) | ||||
NRG1 | Neuregulin 1. (712 aa) | ||||
PTPN12 | Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (757 aa) | ||||
HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (789 aa) | ||||
NRAS | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) | ||||
RPS27A | Ubiquitin-like domain-containing protein. (204 aa) | ||||
CDC37 | CDC37 cell division cycle 37 protein. (380 aa) | ||||
HRAS | HRas proto-oncogene, GTPase. (189 aa) |