STRINGSTRING
APH1A APH1A HRAS HRAS PSEN2 PSEN2 PIK3CA PIK3CA NEDD4 NEDD4 WWP1 WWP1 HBEGF HBEGF APH1B APH1B UBC UBC EREG EREG WWOX WWOX EGFR EGFR NRG2 NRG2 PSEN1 PSEN1 SOS1 SOS1 KXD1 KXD1 ERBB4 ERBB4 GRB2 GRB2 ERBB3 ERBB3 KRAS KRAS PIK3R1 PIK3R1 SHC1 SHC1 SRC SRC ESR1 ESR1 NRG3 NRG3 YAP1 YAP1 NCSTN NCSTN BTC BTC NRG1 NRG1 ITCH ITCH NRAS NRAS PSENEN PSENEN RPS27A RPS27A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PSEN2Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (485 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform 3. (1323 aa)
WWP1E3 ubiquitin-protein ligase. (923 aa)
HBEGFProheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (264 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
EREGEpiregulin. (168 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
NRG2Neuregulin 2. (858 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
ERBB4Receptor protein-tyrosine kinase. (1201 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1342 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
SHC1SHC adaptor protein 1. (583 aa)
SRCTyrosine-protein kinase. (559 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
NRG3Neuregulin 3. (718 aa)
YAP1Yes associated protein 1. (432 aa)
NCSTNNicastrin isoform 1. (709 aa)
BTCEGF-like domain-containing protein. (342 aa)
NRG1Neuregulin 1. (712 aa)
ITCHE3 ubiquitin-protein ligase. (873 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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