STRINGSTRING
JAK2 JAK2 FES FES FYN FYN LYN LYN SOS1 SOS1 TEC TEC SH2B3 SH2B3 CHEK1 CHEK1 GRB2 GRB2 PRKCA PRKCA STAT3 STAT3 GRB7 GRB7 KRAS KRAS I3LDA9_PIG I3LDA9_PIG FER FER PIK3R1 PIK3R1 SH2B2 SH2B2 SRC SRC GRB10 GRB10 CBL CBL VAV1 VAV1 PTPN6 PTPN6 GRAP2 GRAP2 LCK LCK GRAP GRAP NRAS NRAS MMP9 MMP9 HRAS HRAS GAB2 GAB2 PIK3CA PIK3CA LOC100511937 LOC100511937 PTPRU PTPRU PIK3R2 PIK3R2 YES1 YES1 RAC1 RAC1 PTPN11 PTPN11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
FYNTyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
LYNTyrosine-protein kinase. (512 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
TECTyrosine-protein kinase. (632 aa)
SH2B3SH2B adaptor protein 3. (600 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. (476 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
GRB7Growth factor receptor bound protein 7. (569 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
I3LDA9_PIGPeptidase S1 domain-containing protein. (236 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
SH2B2SH2B adaptor protein 2. (695 aa)
SRCTyrosine-protein kinase. (559 aa)
GRB10Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa)
CBLCbl proto-oncogene. (914 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa)
GRAP2GRB2-related adapter protein 2 isoform 1. (320 aa)
LCKTyrosine-protein kinase. (520 aa)
GRAPUncharacterized protein. (313 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GAB2GRB2 associated binding protein 2. (740 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100511937Uncharacterized protein. (532 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1446 aa)
PIK3R2Uncharacterized protein. (772 aa)
YES1Tyrosine-protein kinase. (553 aa)
RAC1Rac family small GTPase 1. (186 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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