STRINGSTRING
NUDT4 NUDT4 INPP5D INPP5D PLCH2 PLCH2 IP6K3 IP6K3 PLCE1 PLCE1 ISYNA1 ISYNA1 PLD4 PLD4 ITPK1 ITPK1 IPMK IPMK INPP4B INPP4B PLCH1 PLCH1 PLCB2 PLCB2 IP6K2 IP6K2 NUDT3 NUDT3 PLCB1 PLCB1 OCRL OCRL INPP5J INPP5J PLCD4 PLCD4 PLCG2 PLCG2 INPP5B INPP5B PLCG1 PLCG1 IPPK IPPK INPP4A INPP4A MINPP1 MINPP1 PTEN PTEN INPP5A INPP5A IP6K1 IP6K1 PLCB3 PLCB3 INPP1 INPP1 PLCD3 PLCD3 PLCD1 PLCD1 NUDT11 NUDT11 PPIP5K2 PPIP5K2 SYNJ1 SYNJ1 PLCB4 PLCB4 PPIP5K1 PPIP5K1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NUDT4Nudix hydrolase domain-containing protein. (180 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1199 aa)
PLCH2Phosphoinositide phospholipase C. (1329 aa)
IP6K3Kinase; Belongs to the inositol phosphokinase (IPK) family. (409 aa)
PLCE1Phosphoinositide phospholipase C. (2316 aa)
ISYNA1Inositol-3-phosphate synthase 1. (556 aa)
PLD4Phospholipase D family member 4. (684 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase. (460 aa)
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (416 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (938 aa)
PLCH1Phosphoinositide phospholipase C. (1690 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa)
NUDT3Nudix hydrolase domain-containing protein. (291 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (903 aa)
INPP5JInositol polyphosphate-5-phosphatase J. (1066 aa)
PLCD41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration [...] (797 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (877 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
IPPKInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (549 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (976 aa)
MINPP1Multiple inositol polyphosphate phosphatase 1 isoform 1; Belongs to the histidine acid phosphatase family. (485 aa)
PTENUncharacterized protein. (576 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (472 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (441 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
INPP1Inositol polyphosphate 1-phosphatase isoform X1. (402 aa)
PLCD3Phosphoinositide phospholipase C. (784 aa)
PLCD1Phosphoinositide phospholipase C. (724 aa)
NUDT11Nudix hydrolase domain-containing protein. (164 aa)
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1282 aa)
SYNJ1Synaptojanin 1. (1576 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1523 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.