(81 nodes) Cell-Cell communication network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PARVB	Parvin beta. (364 aa)
	KRT5	Keratin 5; Belongs to the intermediate filament family. (602 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1709 aa)
	CDH24	Cadherin-24 isoform 2; Cadherins are calcium-dependent cell adhesion proteins. (781 aa)
	TYROBP	TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (109 aa)
	LOC100525346	Uncharacterized protein. (459 aa)
	LAMA3	Laminin subunit alpha 3. (3345 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
	FYN	Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
	TESK1	Dual specificity testis-specific protein kinase 1 isoform X1. (629 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
	CADM2	Cell adhesion molecule 2. (438 aa)
	CD151	Tetraspanin. (264 aa)
	CTNND1	Catenin delta 1. (940 aa)
	CTNNA1	Catenin alpha 1. (1090 aa)
	KIRREL3	Kirre like nephrin family adhesion molecule 3. (794 aa)
	NPHS2	NPHS2 stomatin family member, podocin. (378 aa)
	FLNC	Filamin-C isoform X4. (2720 aa)
	CDH10	Cadherin-10 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (788 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	JUP	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (744 aa)
	CDH9	Cadherin-9 preproprotein; Cadherins are calcium-dependent cell adhesion proteins. (789 aa)
	SIRPA	Uncharacterized protein. (533 aa)
	ILK	Integrin linked kinase. (479 aa)
	CDH4	Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
	ACTN1	Uncharacterized protein. (888 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	CDH18	Cadherin 18; Cadherins are calcium-dependent cell adhesion proteins. (797 aa)
	PARD6G	Par-6 family cell polarity regulator gamma. (364 aa)
	COL17A1	Collagen type XVII alpha 1 chain. (1506 aa)
	SKAP2	Src kinase associated phosphoprotein 2. (423 aa)
	LOC100736623	Ig-like domain-containing protein. (181 aa)
	FYB1	FYN binding protein 1. (837 aa)
	CDH11	Cadherin-11 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (796 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
	CTNNB1	Catenin beta 1. (808 aa)
	LIMS2	LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (357 aa)
	AFDN	Afadin, adherens junction formation factor. (1815 aa)
	DST	Dystonin. (7797 aa)
	CADM3	Cell adhesion molecule 3 isoform 1. (430 aa)
	CDH17	Cadherin-17. (832 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
	PARD6B	Uncharacterized protein. (401 aa)
	NPHS1	NPHS1 adhesion molecule, nephrin. (1239 aa)
	LOC102161654	Uncharacterized protein. (390 aa)
	MEGF11	Multiple EGF like domains 11. (1140 aa)
	ACTG1	Actin gamma 1. (381 aa)
	NCK2	Cytoplasmic protein. (376 aa)
	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor 6. (773 aa)
	CDH15	Cadherin-15 preproprotein; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
	CDH12	Cadherin-12 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
	VASP	Vasodilator stimulated phosphoprotein. (389 aa)
	FLNA	Filamin A. (2897 aa)
	NECTIN3	Nectin cell adhesion molecule 3. (549 aa)
	FBLIM1	Filamin binding LIM protein 1. (415 aa)
	PLEC	Plectin. (5422 aa)
	LIMS1	LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (397 aa)
	CDH6	Cadherin 6; Cadherins are calcium-dependent cell adhesion proteins. (789 aa)
	KRT14	Keratin 14; Belongs to the intermediate filament family. (515 aa)
	CDH1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (925 aa)
	SFTPD	Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. (386 aa)
	CDH8	Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins. (799 aa)
	CDH7	Cadherin-7 isoform 1 preproprotein; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
	CDH13	Uncharacterized protein. (771 aa)
	NECTIN2	Uncharacterized protein. (616 aa)
	RSU1	Ras suppressor protein 1. (281 aa)
	WASL	WASP like actin nucleation promoting factor. (511 aa)
	KIRREL2	Kirre like nephrin family adhesion molecule 2. (711 aa)
	PARD3	Par-3 family cell polarity regulator. (1355 aa)
	FERMT2	Fermitin family member 2. (776 aa)
	PXN	Uncharacterized protein. (1072 aa)
	PARVA	Parvin alpha. (373 aa)
	KIRREL1	Kirre like nephrin family adhesion molecule 1. (773 aa)
	CD47	Leukocyte surface antigen CD47; Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. Plays an important role in memory formation and synaptic plasticity in the hippocampus. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeabili [...] (340 aa)
	PARD6A	Par-6 family cell polarity regulator alpha. (354 aa)
	ITGB4	Integrin beta. (1814 aa)
	F11R	Uncharacterized protein. (347 aa)
	NECTIN4	Nectin cell adhesion molecule 4. (525 aa)
	SDK1	Sidekick cell adhesion molecule 1. (2141 aa)
	CADM1	Cell adhesion molecule 1. (473 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTG1	ENSSSCP00000035521	ENSSSCP00000040911	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Actin gamma 1.	0.926
ACTB	ACTN1	ENSSSCP00000035521	ENSSSCP00000025103	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein.	0.605
ACTB	AFDN	ENSSSCP00000035521	ENSSSCP00000032558	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Afadin, adherens junction formation factor.	0.913
ACTB	CDH1	ENSSSCP00000035521	ENSSSCP00000058117	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.807
ACTB	CDH2	ENSSSCP00000035521	ENSSSCP00000004030	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	0.670
ACTB	CTNNA1	ENSSSCP00000035521	ENSSSCP00000015253	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Catenin alpha 1.	0.936
ACTB	CTNNB1	ENSSSCP00000035521	ENSSSCP00000031836	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Catenin beta 1.	0.705
ACTB	FLNA	ENSSSCP00000035521	ENSSSCP00000048388	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Filamin A.	0.529
ACTB	FYN	ENSSSCP00000035521	ENSSSCP00000004770	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...]	0.617
ACTB	GRB2	ENSSSCP00000035521	ENSSSCP00000018229	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Growth factor receptor-bound protein 2 isoform 1.	0.767
ACTB	ILK	ENSSSCP00000035521	ENSSSCP00000020640	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Integrin linked kinase.	0.496
ACTB	IQGAP1	ENSSSCP00000035521	ENSSSCP00000001984	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	IQ motif containing GTPase activating protein 1.	0.945
ACTB	ITGA6	ENSSSCP00000035521	ENSSSCP00000031111	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Integrin subunit alpha 6; Belongs to the integrin alpha chain family.	0.783
ACTB	ITGB4	ENSSSCP00000035521	ENSSSCP00000069098	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Integrin beta.	0.917
ACTB	KRT14	ENSSSCP00000035521	ENSSSCP00000057471	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Keratin 14; Belongs to the intermediate filament family.	0.424
ACTB	KRT5	ENSSSCP00000035521	ENSSSCP00000000263	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Keratin 5; Belongs to the intermediate filament family.	0.463
ACTB	NCK1	ENSSSCP00000035521	ENSSSCP00000025894	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Cytoplasmic protein.	0.868
ACTB	NCK2	ENSSSCP00000035521	ENSSSCP00000042553	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Cytoplasmic protein.	0.756
ACTB	NPHS2	ENSSSCP00000035521	ENSSSCP00000016461	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	NPHS2 stomatin family member, podocin.	0.540
ACTB	PARVA	ENSSSCP00000035521	ENSSSCP00000064956	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Parvin alpha.	0.911