STRINGSTRING
MLST8 MLST8 PRKAG1 PRKAG1 GABARAPL1 GABARAPL1 MAP1LC3B MAP1LC3B PARK7 PARK7 MTOR MTOR PINK1 PINK1 RRAGC RRAGC ATG14 ATG14 RRAGA RRAGA TOMM5 TOMM5 LAMTOR2 LAMTOR2 PRKAB2 PRKAB2 CHMP4B CHMP4B MAP1LC3A MAP1LC3A TUBB1 TUBB1 FUNDC1 FUNDC1 SRC SRC VIM VIM RRAGD RRAGD UVRAG UVRAG CHMP4A CHMP4A DYNC1I2 DYNC1I2 ATG9A ATG9A PGAM5 PGAM5 ATG4D ATG4D IFT88 IFT88 TUBB4B TUBB4B MFN1 MFN1 ATG16L1 ATG16L1 MAP1LC3C MAP1LC3C PEX5 PEX5 CHMP7 CHMP7 CSNK2A2 CSNK2A2 ATG101 ATG101 DYNC1LI1 DYNC1LI1 ATG7 ATG7 SLC38A9 SLC38A9 NBR1 NBR1 VDAC1 VDAC1 LAMTOR3 LAMTOR3 DYNC1I1 DYNC1I1 RPS27A RPS27A TUBA8 TUBA8 ULK1 ULK1 TUBB6 TUBB6 TUBA1A TUBA1A LAMTOR5 LAMTOR5 USP30 USP30 ATG12 ATG12 TOMM6 TOMM6 TSC2 TSC2 WIPI2 WIPI2 PRKAA2 PRKAA2 PIK3R4 PIK3R4 ATG4C ATG4C SQSTM1 SQSTM1 MFN2 MFN2 MTERF3 MTERF3 MTMR3 MTMR3 HDAC6 HDAC6 DYNC1LI2 DYNC1LI2 ATG4B ATG4B UBC UBC UBE2V1 UBE2V1 GABARAPL2 GABARAPL2 TOMM70 TOMM70 CSNK2A1 CSNK2A1 TOMM40 TOMM40 ARL13B ARL13B WIPI1 WIPI1 LAMTOR4 LAMTOR4 TOMM20 TOMM20 UBE2N UBE2N DYNLL2 DYNLL2 TOMM22 TOMM22 TUBA4A TUBA4A A0A5G2R693_PIG A0A5G2R693_PIG TSC1 TSC1 LAMTOR1 LAMTOR1 TUBAL3 TUBAL3 CHMP3 CHMP3 RHEB RHEB DYNLL1 DYNLL1 LOC100127131 LOC100127131 MTMR14 MTMR14 ATG3 ATG3 CHMP2B CHMP2B WDR45 WDR45 ATG13 ATG13 AMBRA1 AMBRA1 KXD1 KXD1 TOMM7 TOMM7 PRKAG2 PRKAG2 CHMP6 CHMP6 CETN1 CETN1 GABARAP GABARAP RPTOR RPTOR ATG10 ATG10 LOC100510930 LOC100510930 CHMP4C CHMP4C RB1CC1 RB1CC1 ATG9B ATG9B RRAGB RRAGB CHMP2A CHMP2A ATG4A ATG4A CSNK2B CSNK2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MLST8MTOR associated protein, LST8 homolog. (455 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (298 aa)
GABARAPL1Uncharacterized protein. (148 aa)
MAP1LC3BMicrotubule-associated protein 1 light chain 3 beta. (125 aa)
PARK7DJ-1 protein. (189 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PINK1PTEN induced kinase 1. (588 aa)
RRAGCRas related GTP binding C. (440 aa)
ATG14Autophagy related 14. (510 aa)
RRAGARas related GTP binding A. (313 aa)
TOMM5Mitochondrial import receptor subunit TOM5. (51 aa)
LAMTOR2Ragulator complex protein LAMTOR2 isoform 1. (125 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
MAP1LC3AMicrotubule-associated protein 1 light chain 3 alpha. (121 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
FUNDC1FUN14 domain containing 1. (158 aa)
SRCTyrosine-protein kinase. (559 aa)
VIMVimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (469 aa)
RRAGDRas-related GTP-binding protein D. (396 aa)
UVRAGUV radiation resistance associated. (748 aa)
CHMP4ACharged multivesicular body protein 4A. (229 aa)
DYNC1I2WD_REPEATS_REGION domain-containing protein. (581 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (871 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (288 aa)
ATG4DCysteine protease ATG4D, mitochondrial; [Cysteine protease ATG4D]: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C- terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. (514 aa)
IFT88Intraflagellar transport 88. (817 aa)
TUBB4BTubulin beta 4B class IVb; Belongs to the tubulin family. (561 aa)
MFN1Mitochondrial mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (741 aa)
ATG16L1Autophagy-related protein 16-1 isoform X1. (623 aa)
MAP1LC3CMicrotubule associated protein 1 light chain 3 gamma. (147 aa)
PEX5Peroxisomal biogenesis factor 5. (660 aa)
CHMP7Charged multivesicular body protein 7. (505 aa)
CSNK2A2Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa)
ATG101Autophagy-related protein 101 isoform X1. (218 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (710 aa)
SLC38A9Sodium-coupled neutral amino acid transporter 9 isoform X2. (531 aa)
NBR1Next to BRCA1 gene 1 protein isoform X1. (960 aa)
VDAC1Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] (302 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
DYNC1I1Cytoplasmic dynein 1 intermediate chain 1 isoform X1. (645 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (497 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1176 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (411 aa)
TUBA1ADetyrosinated tubulin alpha-1B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
LAMTOR5Ragulator complex protein LAMTOR5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assem [...] (229 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (516 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
TOMM6Translocase of outer mitochondrial membrane 6. (74 aa)
TSC2TSC complex subunit 2. (1836 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (559 aa)
PRKAA25'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1302 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
SQSTM1Sequestosome 1. (451 aa)
MFN2Mitofusin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
MTERF3Transcription termination factor 3, mitochondrial isoform 1. (445 aa)
MTMR3Myotubularin related protein 3. (1215 aa)
HDAC6Histone deacetylase 6. (1159 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (492 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (402 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
UBE2V1UBIQUITIN_CONJUGAT_2 domain-containing protein. (170 aa)
GABARAPL2Uncharacterized protein. (187 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (398 aa)
TOMM40Translocase of outer mitochondrial membrane 40. (400 aa)
ARL13BADP ribosylation factor like GTPase 13B. (469 aa)
WIPI1Uncharacterized protein. (477 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (100 aa)
TOMM20Translocase of outer mitochondrial membrane 20. (152 aa)
UBE2NUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (147 aa)
DYNLL2Dynein light chain. (133 aa)
TOMM22Uncharacterized protein. (207 aa)
TUBA4ATubulin alpha 4a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (618 aa)
A0A5G2R693_PIGTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (517 aa)
TSC1TSC complex subunit 1. (1166 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (204 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
CHMP3Uncharacterized protein. (251 aa)
RHEBUncharacterized protein. (220 aa)
DYNLL1Dynein light chain. (89 aa)
LOC100127131Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (474 aa)
MTMR14Myotubularin related protein 14. (728 aa)
ATG3Autophagy-related protein 3. (320 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
WDR45WD repeat domain 45. (360 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1296 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
TOMM7Mitochondrial import receptor subunit TOM7 homolog; Required for assembly and stability of the TOM complex (By similarity). Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity). (55 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (619 aa)
CHMP6Charged multivesicular body protein 6. (201 aa)
CETN1Centrin 1. (168 aa)
GABARAPUncharacterized protein. (98 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1351 aa)
ATG10Autophagy related 10. (330 aa)
LOC100510930Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (469 aa)
CHMP4CCharged multivesicular body protein 4C. (237 aa)
RB1CC1RB1 inducible coiled-coil 1. (1608 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (923 aa)
RRAGBRas-related GTP-binding protein B long isoform. (374 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (489 aa)
CSNK2BCasein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). (298 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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