(14 nodes) Synthesis of PIPs at the early endosome membrane network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MTMR12	Myotubularin related protein 12. (746 aa)
	VAC14	Protein VAC14 homolog isoform 1. (783 aa)
	INPP4A	Inositol polyphosphate-4-phosphatase type I A. (976 aa)
	PI4K2A	Phosphatidylinositol 4-kinase type 2-alpha. (479 aa)
	INPP5F	Phosphatidylinositide phosphatase SAC2 isoform 1. (1133 aa)
	MTMR2	Myotubularin-related protein 2 isoform 1. (643 aa)
	MTMR4	Myotubularin related protein 4. (1205 aa)
	PI4K2B	Phosphatidylinositol 4-kinase type 2 beta. (598 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1669 aa)
	FIG4	FIG4 phosphoinositide 5-phosphatase. (915 aa)
	MTM1	Myotubularin isoform X3. (603 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2055 aa)
	INPP4B	Inositol polyphosphate-4-phosphatase type II B. (938 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1302 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FIG4	INPP4A	ENSSSCP00000025476	ENSSSCP00000008743	FIG4 phosphoinositide 5-phosphatase.	Inositol polyphosphate-4-phosphatase type I A.	0.906
FIG4	INPP4B	ENSSSCP00000025476	ENSSSCP00000055851	FIG4 phosphoinositide 5-phosphatase.	Inositol polyphosphate-4-phosphatase type II B.	0.906
FIG4	MTM1	ENSSSCP00000025476	ENSSSCP00000034103	FIG4 phosphoinositide 5-phosphatase.	Myotubularin isoform X3.	0.943
FIG4	MTMR2	ENSSSCP00000025476	ENSSSCP00000015894	FIG4 phosphoinositide 5-phosphatase.	Myotubularin-related protein 2 isoform 1.	0.969
FIG4	MTMR4	ENSSSCP00000025476	ENSSSCP00000018696	FIG4 phosphoinositide 5-phosphatase.	Myotubularin related protein 4.	0.914
FIG4	PIK3R4	ENSSSCP00000025476	ENSSSCP00000056139	FIG4 phosphoinositide 5-phosphatase.	Phosphoinositide-3-kinase regulatory subunit 4.	0.457
FIG4	PIKFYVE	ENSSSCP00000025476	ENSSSCP00000054023	FIG4 phosphoinositide 5-phosphatase.	Phosphoinositide kinase, FYVE-type zinc finger containing.	0.998
FIG4	VAC14	ENSSSCP00000025476	ENSSSCP00000002945	FIG4 phosphoinositide 5-phosphatase.	Protein VAC14 homolog isoform 1.	0.990
INPP4A	FIG4	ENSSSCP00000008743	ENSSSCP00000025476	Inositol polyphosphate-4-phosphatase type I A.	FIG4 phosphoinositide 5-phosphatase.	0.906
INPP4A	INPP4B	ENSSSCP00000008743	ENSSSCP00000055851	Inositol polyphosphate-4-phosphatase type I A.	Inositol polyphosphate-4-phosphatase type II B.	0.906
INPP4A	MTM1	ENSSSCP00000008743	ENSSSCP00000034103	Inositol polyphosphate-4-phosphatase type I A.	Myotubularin isoform X3.	0.913
INPP4A	MTMR2	ENSSSCP00000008743	ENSSSCP00000015894	Inositol polyphosphate-4-phosphatase type I A.	Myotubularin-related protein 2 isoform 1.	0.914
INPP4A	MTMR4	ENSSSCP00000008743	ENSSSCP00000018696	Inositol polyphosphate-4-phosphatase type I A.	Myotubularin related protein 4.	0.910
INPP4A	PI4K2A	ENSSSCP00000008743	ENSSSCP00000011214	Inositol polyphosphate-4-phosphatase type I A.	Phosphatidylinositol 4-kinase type 2-alpha.	0.562
INPP4A	PI4K2B	ENSSSCP00000008743	ENSSSCP00000024590	Inositol polyphosphate-4-phosphatase type I A.	Phosphatidylinositol 4-kinase type 2 beta.	0.493
INPP4A	PIK3C2A	ENSSSCP00000008743	ENSSSCP00000025092	Inositol polyphosphate-4-phosphatase type I A.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family.	0.912
INPP4A	PIKFYVE	ENSSSCP00000008743	ENSSSCP00000054023	Inositol polyphosphate-4-phosphatase type I A.	Phosphoinositide kinase, FYVE-type zinc finger containing.	0.914
INPP4B	FIG4	ENSSSCP00000055851	ENSSSCP00000025476	Inositol polyphosphate-4-phosphatase type II B.	FIG4 phosphoinositide 5-phosphatase.	0.906
INPP4B	INPP4A	ENSSSCP00000055851	ENSSSCP00000008743	Inositol polyphosphate-4-phosphatase type II B.	Inositol polyphosphate-4-phosphatase type I A.	0.906
INPP4B	MTM1	ENSSSCP00000055851	ENSSSCP00000034103	Inositol polyphosphate-4-phosphatase type II B.	Myotubularin isoform X3.	0.927