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SPTSSB SPTSSB ORMDL2 ORMDL2 FA2H FA2H CERS3 CERS3 SPTLC3 SPTLC3 SPTLC1 SPTLC1 SAMD8 SAMD8 ALDH3B1 ALDH3B1 ALDH3B2 ALDH3B2 CERS4 CERS4 ORMDL1 ORMDL1 PLPP1 PLPP1 SPHK1 SPHK1 SGPP1 SGPP1 SPHK2 SPHK2 DEGS1 DEGS1 CERS5 CERS5 SPNS2 SPNS2 CERS2 CERS2 ACER2 ACER2 KDSR KDSR ORMDL3 ORMDL3 SPTLC2 SPTLC2 ACER3 ACER3 CERS6 CERS6 ALDH3A2 ALDH3A2 DEGS2 DEGS2 SGPL1 SGPL1 SGMS2 SGMS2 ACER1 ACER1 SGPP2 SGPP2 PLPP2 PLPP2 PLPP3 PLPP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPTSSBSerine palmitoyltransferase small subunit B. (110 aa)
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (371 aa)
CERS3Ceramide synthase 3. (385 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (548 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (473 aa)
SAMD8Sterile alpha motif domain containing 8. (478 aa)
ALDH3B1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (481 aa)
ALDH3B2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (486 aa)
CERS4Ceramide synthase 4. (393 aa)
ORMDL1ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
PLPP1Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these [...] (290 aa)
SPHK1Sphingosine kinase 1 isoform 2. (481 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (443 aa)
SPHK2Sphingosine kinase 2. (653 aa)
DEGS1Sphingolipid delta(4)-desaturase DES1 isoform 1. (323 aa)
CERS5Ceramide synthase 5 isoform X1. (392 aa)
SPNS2Sphingolipid transporter 2. (561 aa)
CERS2Ceramide synthase 2 isoform X1. (524 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (274 aa)
KDSR3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (337 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (173 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (561 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (324 aa)
CERS6Ceramide synthase 6. (392 aa)
ALDH3A2Aldehyde dehydrogenase 3 family member A2; Belongs to the aldehyde dehydrogenase family. (578 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (341 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (609 aa)
SGMS2Phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X1. (365 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2 isoform a. (399 aa)
PLPP2Phospholipid phosphatase 2. (368 aa)
PLPP3acidPPc domain-containing protein. (369 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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