(39 nodes) Glycosphingolipid metabolism network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NEU4	Neuraminidase 4. (471 aa)
	B4GALNT1	Beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X5. (671 aa)
	NEU1	Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage (By similarity). (432 aa)
	SMPD2	Sphingomyelin phosphodiesterase 2. (423 aa)
	GBA2	Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (915 aa)
	ASAH1	N-acylsphingosine amidohydrolase 1. (489 aa)
	SUMF2	Sulfatase-modifying factor 2 isoform b. (301 aa)
	ARSK	Arylsulfatase family member K. (540 aa)
	ARSI	Arylsulfatase family member I. (570 aa)
	SMPD1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (640 aa)
	GLB1L	Galactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family. (651 aa)
	NEU2	Neuraminidase 2. (379 aa)
	ARSJ	Arylsulfatase family member J. (601 aa)
	ENPP7	Ectonucleotide pyrophosphatase/phosphodiesterase 7. (473 aa)
	ESYT3	Extended synaptotagmin 3. (889 aa)
	GALC	Galactocerebrosidase isoform a. (685 aa)
	GLB1	Beta-galactosidase. (614 aa)
	UGCG	UDP-glucose ceramide glucosyltransferase. (394 aa)
	LOC100621771	Sulfatase domain-containing protein. (583 aa)
	NEU3	Neuraminidase 3. (428 aa)
	SUMF1	Sulfatase modifying factor 1. (374 aa)
	ARSG	Arylsulfatase G. (525 aa)
	ARSB	Arylsulfatase B. (540 aa)
	HEXA	Beta-hexosaminidase. (545 aa)
	STS-2	Sulfatase domain-containing protein. (555 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (656 aa)
	GLA	Alpha-galactosidase. (433 aa)
	ESYT2	Extended synaptotagmin 2. (863 aa)
	SMPD4	Sphingomyelin phosphodiesterase 4 isoform 2. (868 aa)
	B3GALNT1	UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development. (331 aa)
	CERK	Ceramide kinase. (536 aa)
	UGT8	UDP glycosyltransferase 8; Belongs to the UDP-glycosyltransferase family. (556 aa)
	ASAH2	Neutral ceramidase. (786 aa)
	GM2A	Ganglioside GM2 activator isoform X1. (193 aa)
	ARSA	Sulfatase domain-containing protein. (519 aa)
	ESYT1	Extended synaptotagmin 1. (1109 aa)
	ARSL	Arylsulfatase E. (612 aa)
	CTSA	Carboxypeptidase; Belongs to the peptidase S10 family. (485 aa)
	GBA3	Glucosylceramidase beta 3 (gene/pseudogene); Belongs to the glycosyl hydrolase 1 family. (469 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSA	ARSB	ENSSSCP00000069615	ENSSSCP00000037802	Sulfatase domain-containing protein.	Arylsulfatase B.	0.942
ARSA	ARSG	ENSSSCP00000069615	ENSSSCP00000037457	Sulfatase domain-containing protein.	Arylsulfatase G.	0.909
ARSA	ARSI	ENSSSCP00000069615	ENSSSCP00000015379	Sulfatase domain-containing protein.	Arylsulfatase family member I.	0.581
ARSA	ARSJ	ENSSSCP00000069615	ENSSSCP00000018124	Sulfatase domain-containing protein.	Arylsulfatase family member J.	0.581
ARSA	ARSK	ENSSSCP00000069615	ENSSSCP00000015034	Sulfatase domain-containing protein.	Arylsulfatase family member K.	0.571
ARSA	ARSL	ENSSSCP00000069615	ENSSSCP00000070779	Sulfatase domain-containing protein.	Arylsulfatase E.	0.473
ARSA	GALC	ENSSSCP00000069615	ENSSSCP00000021318	Sulfatase domain-containing protein.	Galactocerebrosidase isoform a.	0.948
ARSA	GLA	ENSSSCP00000069615	ENSSSCP00000051974	Sulfatase domain-containing protein.	Alpha-galactosidase.	0.939
ARSA	GM2A	ENSSSCP00000069615	ENSSSCP00000069089	Sulfatase domain-containing protein.	Ganglioside GM2 activator isoform X1.	0.523
ARSA	LOC100621771	ENSSSCP00000069615	ENSSSCP00000026776	Sulfatase domain-containing protein.	Sulfatase domain-containing protein.	0.479
ARSA	NEU1	ENSSSCP00000069615	ENSSSCP00000001513	Sulfatase domain-containing protein.	Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage (By similarity).	0.949
ARSA	NEU2	ENSSSCP00000069615	ENSSSCP00000017266	Sulfatase domain-containing protein.	Neuraminidase 2.	0.900
ARSA	NEU3	ENSSSCP00000069615	ENSSSCP00000034065	Sulfatase domain-containing protein.	Neuraminidase 3.	0.907
ARSA	NEU4	ENSSSCP00000069615	ENSSSCP00000045378	Sulfatase domain-containing protein.	Neuraminidase 4.	0.910
ARSA	STS-2	ENSSSCP00000069615	ENSSSCP00000043119	Sulfatase domain-containing protein.	Sulfatase domain-containing protein.	0.460
ARSA	SUMF1	ENSSSCP00000069615	ENSSSCP00000035016	Sulfatase domain-containing protein.	Sulfatase modifying factor 1.	0.801
ARSA	SUMF2	ENSSSCP00000069615	ENSSSCP00000008273	Sulfatase domain-containing protein.	Sulfatase-modifying factor 2 isoform b.	0.688
ARSA	UGT8	ENSSSCP00000069615	ENSSSCP00000058338	Sulfatase domain-containing protein.	UDP glycosyltransferase 8; Belongs to the UDP-glycosyltransferase family.	0.948
ARSB	ARSA	ENSSSCP00000037802	ENSSSCP00000069615	Arylsulfatase B.	Sulfatase domain-containing protein.	0.942
ARSB	ARSG	ENSSSCP00000037802	ENSSSCP00000037457	Arylsulfatase B.	Arylsulfatase G.	0.930